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AI and science frontiers · 2026-10-27

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LMSYS Org

When a long-context request dies mid-transfer, its KV cache can land in someone else's output: SGLang now holds slots until writes drain

SGLang closed a cross-request KV cache exposure in disaggregated prefill/decode serving: after a request aborts mid-transfer, RDMA writes it already launched can still land and overwrite another request's cache. Decode now keeps the aborted request's slots until every notified prefill rank acknowledges a drain or a bounded timeout fires, default-on for Mooncake and NIXL from v0.5.21, with throughput deltas within ±2% on 2×H100.

Before diffusion models generalize, they grow spurious attractors absent from training data but repeated in samples

As the training set grows, diffusion models move from memorizing training samples to generalizing, and between these phases an intermediate kind of attractor appears that matches no training image yet recurs in generated samples. Reading generation as retrieval in a dense associative memory predicts such spurious states once storage capacity is exceeded; on MNIST, FASHION-MNIST, CIFAR-10 and LSUN-CHURCH the spurious fraction rises and then falls at the memorization-to-generalization boundary, with basin volumes between those of memorized and generalized samples.

A single-cell reference can flip the verdict: CD8 T-cell age link reverses in all 80 six-type references

Cell proportions from bulk RNA sequencing are inferred through a single-cell reference, and that reference can change the conclusion drawn from them. In 981 PBMC donors the CD8 T-cell age association reversed in all 80 six-type references and the CD4 slope was inflated about 6.3-fold; in 48 islet donors a borderline alpha-cell association became significant in 54% to 100% of references. The error recurred across four estimator classes, its direction was set by the estimator, and fit accuracy did not flag it.

arXiv

Private vector search stops scaling with database size: HNSecW brings online ANN queries to logarithmic time while holding recall at billion scale

In the symmetric-privacy setting where both the query and the database must stay hidden, HNSecW turns HNSW graph-index approximate nearest neighbor search into a fully data-independent procedure that runs under secure multi-party computation, giving single-query online communication and local computation logarithmic complexity. Earlier protocols of this kind mostly used cluster-based pipelines whose online communication grows linearly with database size. On million- to billion-scale benchmarks, HNSecW keeps recall comparable to plaintext HNSW and reaches up to orders-of-magnitude end-to-end speedup over 2PC PANTHER on a wide-area network.

Calibrated uncertainty often fails to beat random sampling: active learning on out-of-distribution materials data

Active learning for materials and molecular property prediction treats high-uncertainty samples as the information a model is missing. Across formation energy, bandgap and solubility tasks, uncertainty came from loss-landscape sampling and from ensembles retrained with different seeds, then was calibrated with linear calibration factors and a neural network. Calibrated uncertainty generally did not reduce the data a model needed to improve on out-of-distribution data, showing no advantage over random sampling or uncalibrated estimates, and error bars overlapped.

arXiv

95% intervals calibrated on random splits fail outside the training envelope: hard-shift coverage falls to 0.40–0.75 across seven engineering datasets

Prediction intervals for engineering regression are usually calibrated on random splits, while deployment happens outside training conditions. A benchmark splits seven public engineering datasets into in-distribution, soft-shift and hard-shift rungs along physically meaningful shift variables, and compares 12 uncertainty quantification methods from five families tuned on source data only. In distribution, conformal methods cover at least 0.946 on every dataset; under hard shift, mean coverage falls to 0.40–0.75 for the 11 methods that always return an interval, and no systematic difference in method ranks is detected.

Enzyme kinetics prediction learns pairwise differences: kcat R² of 0.71 under cold start, zero-shot PCC of 0.40 on external adenylate kinase data

Enzyme kinetics prediction has relied on absolute regression over heterogeneous data, where the same enzyme-substrate system can differ by orders of magnitude across studies and models drift toward the mean. DeltaKcat recasts the task as pairwise relative learning: within one study it fixes either the enzyme or the substrate and a siamese network predicts the kinetic difference between two enzyme-substrate complexes, after which an experimentally characterized reference complex restores absolute values. Under a cold-start split, absolute kcat prediction reaches R² 0.71 and PCC 0.85, against R² 0.14 to 0.48 for DLKcat, CataPro and UniKP; on external adenylate kinase data excluded from training, zero-shot PCC is 0.40.

Emotion-reading robots can be fooled: attacked accuracy falls below 0.16 while confidence stays at 0.964

Facial emotion recognition for human-robot interaction is usually judged by clean-set accuracy, yet a robot that maps an emotion estimate to an action also needs to know whether that estimate can be trusted. Comparing five pipelines on a five-class FER2013 subset, the strongest deep residual CNN reaches 0.760 accuracy and 0.753 macro-F1 but collapses with every other trained architecture under gradient attacks: FGSM drops all four below 0.16 accuracy at epsilon 0.01, and PGD drives them near zero at epsilon 0.02 and above. The attacked predictions stay confident, with mean confidence 0.964 under PGD and 96.0% still above a 0.70 threshold after temperature scaling, so thresholding the maximum softmax probability does not separate legitimate from adversarial predictions.

arXiv

Instruction-hierarchy training missed one conflict type: adding goal-goal pairs lifts Qwen3.5-9B conflict resistance by 34.3 points

Existing instruction-hierarchy training sets cover constraint-constraint and constraint-goal conflicts but not two goals that conflict with each other. Decomposing a task into goals and constraints yields 9,544 goal-goal preference pairs built from two text-processing instructions that each process the other's message, and fine-tuning Qwen3.5-9B and Gemma4-12B-it on them with direct preference optimization raises mean conflict resistance by 34.3 and 19.4 points on four instruction-hierarchy benchmarks unseen in training, with small mean utility changes across eight benchmarks.

medRxiv

Blood smears stop at 200 cells: a neural cellular automaton scans the whole slide and holds F1 0.79 across centers

Automated blood and bone marrow smear analysis had been confined to manually selected regions of interest because gigapixel whole-slide scanning is computationally heavy. HemAutomaton uses a neural cellular automaton to locate white blood cells across entire slides without manual region selection, matching Faster R-CNN in-domain detection and reaching a mean cross-domain F1 of 0.79 versus 0.65, with 3.3k trainable parameters against 41.4M. Across three blood cancer cohorts it extracted 108 million single-cell images and performed automated differential counting through few-shot classification with a pretrained hematology foundation model.

medRxiv

Cancer side effects can be forecast from routine labs: SPARC holds up across 11 hospitals

Predicting cancer treatment side effects has long relied on static nomograms built from a handful of variables. SPARC instead models longitudinal sequences of blood counts, metabolic panels and vital signs, pretraining on 101,920,379 measurements from 224,047 patients and then fine-tuning for mortality, anemia, neutropenia, febrile neutropenia, acute kidney injury and liver toxicity. It matched or led comparison models on held-out, prospective and multi-hospital cohorts, and its predicted risk strata identified patients most likely to benefit from G-CSF prophylaxis.

medRxiv

Ewing sarcoma survival splits by neighborhood, not mutation: a 135-patient spatial map yields four prognostic types, with interferon-reactive tumors faring best

Ewing sarcoma is genomically near-uniform yet patients fare very differently. Single-cell and spatial transcriptomics of tumors and their microenvironment in 135 patients identified five tumor-cell transcriptional states and eight niches defined by neighboring cell configurations, and niche composition sorted patients into Fusion Active, Proliferative, Immune Reactive and TME-enriched types. The Immune Reactive type, marked by interferon-activated tumor cells, had favorable survival, and the survival differences reproduced in two independent bulk transcriptomic cohorts.

medRxiv

Activity tracking beyond totals: disease-enriched local patterns split hypertension and diabetes into two phenotypes

Wearable accelerometers record activity around the clock, but summary measures and population-wide clustering can miss disease-associated behavioral differences. LocPA adjusts hourly activity profiles for age, sex and body mass index, then tests local disease enrichment on a similarity network and groups enriched neighborhoods into patterns. In UK Biobank 24-hour accelerometry, a low-activity and a sleep-disrupted phenotype recurred across six diseases; in hypertension and diabetes the sleep-disrupted group carried greater disease burden, while average acceleration and moderate-to-vigorous activity time did not follow that ordering.

arXiv

Whole-network one-way switching: about two thirds of roads flip to the peak direction at rush hour, cutting daily delay by roughly 80%

Lane directions and speed limits across an urban network are now set jointly at every decision step by one transformer shared by all road controllers, passed through a check grounded in graph orientation theory that keeps every junction mutually reachable at all times. On a grid with commuter rush hours, the learned policy makes about two thirds of roads one-way in the peak direction and cuts daily delay by roughly 80% against holding the initial two-way configuration all day, and by roughly 70% against a tuned two-way load balancer. Restricted to two-way roads at test time, it gains only about as much as that balancer, and its learned speed limits add delay.

arXiv

Finer process rewards are not automatically better: decaying the weight lifts long-horizon trailer editing by 45.4%, while a fixed weight truncates 44.1% of rollouts

On four trailer-editing task types built from 49 real films and their released trailers, decaying an LLM-judged turn-level process reward to zero within the same GRPO setup gives a 45.4% relative gain over outcome-only GRPO on Fine Cut, while the fixed-weight variant scores below outcome-only GRPO on the three shorter task types and truncates 44.1% of rollouts. Process rewards do encourage visual inspection and reasoning early, but continued optimization drives redundant tool calls without a committed result; token-level on-policy self-distillation proves highly sensitive to the teacher's privileged information.

arXiv

One self-supervised encoder lifts CWRU fault-classification macro-F1 from 0.350 to 0.812, but not remaining-useful-life accuracy

Across 47 public PHM datasets harmonized to one tensor contract, an 801,808-parameter channel-independent Transformer encoder pretrained with masked patch prediction raises fault-classification macro-F1 from 0.350 to 0.812 on the fully withheld CWRU set and from 0.569 to 0.951 on HSG18, with frozen linear probing alone reaching 0.705 and 0.906; the same pretraining does not reliably beat a from-scratch baseline on CMAPSS remaining-useful-life estimation. Simulated federated pretraining over ten clients grouped by physical domain retains part of the representation but trails the centralized encoder at matched budget, and the self-supervised loss does not predict downstream utility.

arXiv

Vehicles Leave After One-Shot Training: Exact Federated Editing Cuts Cumulative Time 36%–44% in Mobility Simulation

One-shot federated learning finishes training in a single communication round, but the resulting model is frozen once devices join or leave, leaving full retraining as the fallback. F-SOSA draws a fixed-size uniform random client subset so outputs under neighboring device sets stay bounded in total variation, then rewrites curvature-aware fusion as a projection over client-additive sufficient statistics, enabling F-SOSA-U for withdrawing a contribution and F-SOSA-I for adding one. In a SUMO urban mobility simulation, both match retraining accuracy while cutting cumulative time and communication by 36%–44% and 22%–33%.

aclanthology.org

Medical vision-language models get a calibration stress test: 1,638 controlled runs expose where confidence breaks

Evaluation of medical vision-language models has centered on accuracy, leaving whether their confidence is trustworthy largely untested. MVC-Bench splits calibration into three axes, robustness, effectiveness of calibration and prompt-tuning methods, and stability under prompt templates and random seeds, spanning fundus, histopathology and chest X-ray modalities, eight backbones and six prompt-tuning methods across 1,638 controlled experiments. In-domain calibration rankings barely survive domain shift, with a mean Kendall correlation of -0.0598 over 30 rank-transfer tests and none significantly positive; the proposed Multi-Class Margin regularizer reaches the lowest ECE in 10 of 12 in-domain settings but only 4 under domain shift.

arXiv

Web-search agent evaluation keeps the real trail: flagged failure nodes link back to the answer groups that went wrong

Evaluations of long-horizon web-search agents have leaned on simulated trajectories or on trails reconstructed from final answers, which makes the search process itself hard to inspect. LongSearchEval runs 16 models on 100 tasks under one shared agent controller and five restricted web tools, retains 1,600 real trajectories, verifies answer groups against the webpages the agent itself cited, then links flagged failure nodes to groups judged incorrect. Human review agrees with 94.50% of automatic judgments on 946 answer groups, and 311 of 317 sampled round-to-group links pass a feature-correspondence check.

NVIDIA puts a checkpoint before agent skills install: 26.1% of 31,132 scanned skills carry vulnerabilities

AI agent skills run on implicit trust and get little vetting before installation. NVIDIA's open-source SkillSpector scans a repository, zip file, directory or single file before install, covering 71 vulnerability patterns in 17 categories with fast static analysis and an optional LLM semantic pass. In the 31,132-skill analyzed subset of its research dataset, 26.1% of skills contain vulnerabilities and 5.2% show likely malicious intent.

bioRxiv

Olive repeats get a genome-wide read: three plant DNA models agree on which STR loci shift their embeddings

Olive short tandem repeats (STRs, stretches whose repeat-unit copy number varies) had been read mainly through small microsatellite panels, leaving genome-wide variation and interpretation open. Across 212 Iranian and Mediterranean olive accessions, the study catalogued 117,119 polymorphic STR loci and passed natural allele series through three plant genomic language models, AgroNT, PlantCAD2 and GPN, measuring how far embeddings move as repeat length departs from the reference allele. On 62,847 loci, the three models shared 7,417 embedding-sensitive loci, and at most tested loci STR responses exceeded length-matched nonrepetitive indels.

Recursive training gets a thermostat: closed-loop control cuts collapse risk from 2.67 to 0.48 and keeps 97.4% of the tail

Generative models retrained on their own output narrow their distribution and lose the tails first, and training pipelines have lacked a way to correct this while they run. HOMEOSTASIS fuses signed, hash-chained provenance records with three model vital signs, predictive entropy, calibration error and representational drift, into a Lyapunov-style collapse-risk score, and a PID controller adjusts the human-data mixing ratio and quarantine decisions. On a five-dimensional Gaussian recursion over 30 seeds and 20 generations, closed-loop control lowered final collapse risk from 2.67 to 0.48 and held tail coverage at 97.4% against 66.2% without control, while provenance-gated quarantine showed no detectable benefit beyond control alone.

aclanthology.org

Multimodal quantization stops text from drowning out vision: one shared transform reconciles both gradients, 66.51 average on the 32B model at W4A6

When a multimodal large language model is quantized to low bit-widths, text and vision tokens must learn one shared channel-wise transform, and their gradients can point in opposite directions or differ wildly in magnitude. MCTQ splits the reconstruction objective by modality, then combines the two gradients into a single update direction through a minimum-norm convex combination, keeping one shared transform and adding no inference overhead. On Qwen2.5-VL-7B at W4A6 it reaches 66.26 average accuracy, 1.30 points above OmniQuant; Qwen2.5-VL-32B reaches 66.51 in the same setting.

sarvam.ai

Enterprise agents stop re-reading documents per question: a knowledge tree plus ontology lifts Harvey LAB rubric pass rate from 55.1% to 84.2%

Sarvam built a knowledge fabric for enterprise agents that compiles documents once into a navigable knowledge tree and a queryable domain ontology, so agents locate material by directory and filter by entity instead of re-retrieving passages for every question. On Harvey's LAB law-firm benchmark with GLM 5.3 as the agent model, answers met 84.2% of expert rubric criteria versus 55.1% for agentic RAG, while average task cost fell from $0.64 to $0.28; on Sierra's tau-knowledge banking benchmark with GLM 5.2, the fabric matched baseline accuracy using 64% fewer tokens.

medRxiv

Bacterial ID stops chasing exact species: pooling 13-species single-cell images into AST-routing groups lifts accuracy from 65.4% to 77.1%

Single-cell image classification struggles to name species on unseen strains. SC-MAPS aligns phase-contrast, bright-field and three fluorescence channels on 916,435 cells from 13 species and fuses them with deep learning; on held-out strains single-cell species accuracy is 65.4%, pooling species probabilities into eight AST-routing groups raises it to 77.1%, and combining five cells from one sample reaches 91.1%.

Same refund call, different authority: separating purpose from effect cuts worst-case direct-harm pass-through from 100% to 34.5% under mislabelled channels

When an institutional AI agent proposes a tool call, the same refund may come from an authorised tax officer or from an instruction hidden in the petition it was asked to summarise. This authorisation guard keeps separate neutrosophic triples for effect and for purpose, discounts evidence by channel trust, fuses it, and then authorises, escalates or denies. On 1,054 InjecAgent attack cases, retaining ambivalence about an unrequested call lowered worst-case direct-harm pass-through after channel mislabelling from 100% to 34.5%, and to 25.0% on synthetic e-government scenarios.

Neural-state segmentation stops rebuilding templates per candidate: reused interval statistics cut the same fit by up to 1,730 times

Greedy State Boundary Search (GSBS) finds transitions between stable neural activity patterns, but it rebuilt state templates and recomputed correlations for every candidate boundary, making analyses across recordings and settings expensive. HP-GSBS rewrites the matching objective as additive interval contributions and computes t-distance from reusable correlation statistics, adding streaming candidate reduction, sequential local refinement and active-block reuse across CPU, PyTorch CUDA and Triton paths. Across seven controlled workloads with two input realizations each, median same-input speedups range from 154 to 1,730, and all 168 optimized executions reproduce complete reference boundary histories and selected state counts, with a maximum absolute t-distance difference of 1.88×10⁻¹¹.

NaceAI

Agents stop paging through files: Drex for Search picks the spot first, cutting steps 62% and input tokens 56% across 529 questions

When an AI agent needs an answer from a real folder of reports, ledgers and contracts, it searches, opens a file, reads pages and searches again, sometimes for twenty or thirty steps. Drex for Search moves that decision earlier: before the agent reads anything, the decision model Drex decides which folder, file and page can hold the answer, and inside a spreadsheet which table and column, so the agent reads only those places and returns the source. Across 6 professional-work benchmarks and 529 questions, coding agents using it took 62% fewer steps and 56% fewer input tokens, raised accuracy from 63.1% to 67.1%, and cut median time per question from 80.8 s to 35.5 s.

bioRxiv

Flu vaccine effectiveness gets a preseason number: topological model puts H1N1 at 40.3% and H3N2 at 56.9%

For the 2026–2027 U.S. influenza season, vaccine effectiveness has been forecast by component before the season starts: the topological model gives 40.3%, 56.9% and 47.1% against A(H1N1)pdm09, A(H3N2) and B/Victoria, and the geometric model gives 34.0%, 56.8% and 51.1%. The inputs are 87 hemagglutinin sequences collected in August–September compared with that season's vaccine strains through two mathematical distances, fed into linear regressions fitted on 26 historical season-component observations. These are component point forecasts, not an overall seasonal estimate, with 95% prediction intervals roughly 52–58 percentage points wide, to be checked against final US Flu VE Network estimates.

Causal pairs pulled from nuclear event reports now carry a confidence score: reviewing the top 20% catches 82% of extraction errors

Large language models extract cause-effect pairs from nuclear Licensee Event Reports as flat assertions, leaving risk analysts unable to separate reliable relations from spurious ones. A study stacks four signals, token-level probabilities, self-consistency across stochastic decoding runs, disagreement among three independently fine-tuned models, and conformal prediction, into a calibrated confidence score per pair. On a held-out test set the integrated score reached an expected calibration error of 0.067 and an AUROC of 0.84, above every individual signal, and uncertainty-guided review found 82% of extraction errors within the first 20% of relations reviewed, against 24% for random selection.

VR football viewers get a four-channel immersion readout: video, audio, EEG and gaze fused to 81.6% four-level accuracy

Judging how immersed a VR football viewer is at a given moment is hard from pictures alone, since video cannot tell watching from disengagement, and naive concatenation of four signals carries low-quality channel noise into the decision. CMAFNet treats video as a semantic hub, runs bidirectional cross-attention with audio, EEG and eye tracking, weights each modality per sample by real-time signal quality, and uses an ordinal regression loss to keep immersion levels ordered. On 86,400 samples cut from 720 sixty-second VR match clips, four-level classification reaches 81.6% overall accuracy and 0.274 mean absolute error, 3.4 points above and 13.8% below the strongest 2024 baseline, MT-AMW.

arXiv

Brain connectomics stops scanning every slice slowly: ZoomSEM rebuilds 16× detail from real low-resolution SEM scans

Serial electron microscopy is the workhorse of brain connectomics, yet imaging a cubic millimeter of brain takes months to years. ZoomSEM trains a super-resolution model on real low- and high-resolution SEM image pairs and recovers 4×, 8× and up to 16× higher-resolution images from fast low-resolution scans while preserving the fine neuronal structures connectomic analysis needs, reaching up to 30-fold effective acceleration. Experiments across datasets of diverse biological samples show robust generalization under realistic low-resolution acquisition.

aclanthology.org

RNA inverse folding stops reading only the backbone: treating molecular surface as a design constraint tops sequence recovery on all three benchmarks

RNA inverse folding recovers a nucleotide sequence from a target 3D structure, and earlier methods leaned on secondary structure and backbone topology while rarely constraining the molecular surface that shapes intermolecular interactions. gRFold fuses a surface point cloud, a backbone graph and secondary structure through hierarchical cross-attention to drive autoregressive decoding, then re-ranks candidates at inference by agreement between predicted folds and the target base-pairing pattern. On the RNA-protein complex, monomeric RNA and RNA-Puzzles benchmarks, gRFold reaches sequence recovery of 49.65%, 51.67% and 45.00%, the highest among the compared methods, and ablations show the surface and backbone branches contribute complementary gains.

OpenAI News

OpenAI's GPT-6.1 Terra halves standard API prices and doubles Terminal-Bench 4.0 solve rate

OpenAI released GPT-6.1 Terra, a fast, efficient model combining detailed visual reasoning with precise computer use, priced 50% below GPT-5.6 Terra and GPT-6.1 Sol on the standard API. On Agents' Last Exam at medium reasoning effort it scores 15 percentage points above GPT-5.6 Terra at about one-third the cost, and on Terminal-Bench 4.0 at maximum effort it solves 50.3% of tasks versus GPT-5.6 Terra's published 21.5%. OpenAI notes that GPT-6.1 Sol and GPT-6 Astra remain the better choice for the most complex coding tasks.

arXiv

Graph generation stops leaning on task-specific heuristics: hazard-guided sampling cuts steps on molecular and synthetic graphs

Discrete flow matching (DFM) decouples graph-generation training from sampling, but existing graph DFM samplers often rely on task-specific heuristics and need sampling budgets comparable to diffusion, so the speedup potential is only partly realized. H-GLow decomposes the continuous-time Markov chain generator into hazards and conditional jump distributions, then uses both to plan graph edits and adjust sampling time to graph activity. Adaptable to pretrained graph DFM models, it reports better generation quality with substantially fewer sampling steps on molecular and synthetic graph benchmarks; a companion graph DFM model predicts hazards and conditional jumps directly, with a training objective that decomposes exactly into hazard matching and hazard-weighted jump prediction.

Multi-pinhole SPECT drops the CT attenuation map: one network separates overlapping projections and corrects attenuation and scatter

Multi-pinhole SPECT gains sensitivity but stacks overlapping projections with attenuation, scatter, quantum noise and aperture effects, and attenuation correction usually needs an attenuation coefficient map from X-ray CT. A U-Net++ convolutional network takes Monte Carlo-simulated overlapping projections as input and ray-traced ideal projections as target, separating overlaps and correcting the degradations together before maximum-likelihood expectation-maximization reconstruction. On 60 public brain cases under quasi-stationary acquisition, it reached NMSE 0.18±0.02, PSNR 18.42±0.69 dB and SSIM 0.81±0.04, better than 11-pinhole reconstruction and fan-beam reconstruction with 20-fold longer acquisition.

Synthetic health records can now carry a privacy guarantee: attack detection near chance at ε=8, clinical validity 0.961

Synthetic electronic health records have long traded clinical fidelity against formal privacy guarantees. SynthEHR-DP combines a mixed-type encoder, a temporal transformer encoder and a conditional variational autoencoder, trained under differentially private stochastic gradient descent with Rényi privacy accounting, then applies a post-hoc clinical constraint layer that spends no privacy budget. On MIMIC-IV at a total budget of ε=8 and δ=10⁻⁵, membership inference AUC is 0.52, downstream TSTR AUROC is 0.786, 4.2% below the non-private TRTR oracle of 0.821, and the clinical validity score is 0.961.

arXiv

Assistive agents in shared driving learn to guess intent first, improving torque alignment and collision rate in racing and urban driving

Assistive agents in shared control must act on the human's intent while staying legible enough for the human to respond in real time. Dream2Assist adds intent inference to a recurrent state-space world model and trains the assistive policy through fictitious co-play, anticipating discrete human objectives without overriding human agency. Three human-subjects studies and a preliminary on-vehicle deployment span high-speed racing (N=30) and urban driving with richer intent structure (N=10), where intent conditioning yields measurable improvements in torque alignment and collision rate.

arXiv

Brain age from white matter fiber orientation: 3.54-year mean error across 692 people, and predictions rotate with the input

Brain age prediction no longer relies only on diffusion tensor scalar metrics: white matter fiber orientation distributions (WM-FODs) enter directly as spherical harmonic coefficients, processed by an SE(3) equivariant CNN that preserves their transformation properties under rotation. On 692 participants aged 36-90 from the Human Connectome Project Aging dataset, this combined framework outperformed the evaluated DTI-based models and conventional CNNs; averaging five cross-validation models gave a mean absolute error of 3.54 years and a Pearson correlation of 0.958. The advantage depended on combining WM-FODs with equivariant processing, and accuracy was highest at maximum spherical harmonic order Lmax = 2.

Patient identity hides in Raman spectra: adversarial training cuts ID prediction from 68% to 12% while IDH typing holds at 0.8

In glioma Raman spectra, a single spectrum is enough for a model to tell which patient it came from, a sample-specific bias unrelated to biology that can confound tumor typing. On the 46-sample APOLLO dataset, a learnable feature-importance layer is trained adversarially against a two-headed classifier to suppress patient-identity signal while keeping IDH mutation information. Patient-ID balanced accuracy falls from 68% to 12%, while mutant-versus-wild-type classification stays at 0.8 balanced accuracy.

Fractional diffusion solvers stop paying for memory at every step: precomputed Hermite weights bring relative L2 error to 1.98×10⁻⁵

A neural collocation scheme for semilinear time-fractional reaction–diffusion equations rewrites the Caputo memory term as cubic-Hermite product integration, using the network state and its autodifferentiated time slope as endpoint data on each time panel while the weakly singular weights are precomputed once before training. On the scalar benchmark v(t)=t4.2 the Hermite memory approximation is three to six orders of magnitude more accurate than the classical L1 formula on the tested meshes, and for a manufactured problem with α=0.7 a small CPU-trained network reaches a relative L2 error of 1.98×10⁻⁵ and a maximum error of 3.80×10⁻⁵.

Anesthesia depth stops relying on population averages: per-patient calibration brings BIS prediction error to 11.77%

Predicting the bispectral index (BIS) during balanced anesthesia with sevoflurane or desflurane alongside propofol and remifentanil has relied on fixed population pharmacodynamic parameters. A computational modelling study merged all three drugs into one response-surface model and fitted per-patient sensitivity parameters from 20 real surgical records using artifact-resistant global optimization. With personalized parameters the cohort mean MDAPE was 11.77%, below the 15% clinical viability threshold; a population baseline aggregated from the same cohort gave 16.98%.

arXiv

Streaming predictions need not reread history: ReMAQ turns model-averaging updates into one quadratic program per batch

In real-time prediction over streaming data, an investigator often holds several generalized linear models at once, while model averaging is typically a convex optimization over all historical data. ReMAQ replaces that procedure with a quadratic approximation, so when a new batch arrives the averaged prediction is updated sequentially by solving one quadratic program, without accessing the entire history. Under regularity conditions its weights are asymptotically equivalent to oracle model averaging built on the inaccessible full data, which establishes asymptotic optimality; simulation studies and an application to the Airline On-Time Performance Dataset assess the method.

Modular XL-MIMO beam training stops sweeping the full codebook: parallax lays out candidates, statistics prune the noise-only sectors

Beam training for modular extremely large antenna arrays in hybrid near- and far-field environments no longer keeps a fixed candidate codebook. Prior subarray schemes relied on predefined codebooks or activation patterns and adapted poorly to spatially non-stationary channels; this scheme builds a parallax-aware initial codebook covering each subarray's angular shift, then learns online with a multi-armed bandit, and once a statistical steady state is detected it projects beams across subarrays and prunes noise-only sectors with a likelihood ratio test, compressing the action space. In simulation the scheme's effective spectral efficiency exceeds three comparison schemes across the evaluated SNR range, with markedly reduced training overhead.

arXiv

No Formal Answer, Still Learnable: Reward Training Lifts Spontaneous Correct Refusal From 25% to 100%

On evidence-sufficiency judgment, a domain with no decidable correctness reward, a boundary-keeping recipe of supervised fine-tuning followed by GRPO on an LLM-judge reward raised spontaneous correct refusal under action pressure from 25% in the instruction-tuned baseline to 100% (40 per arm; Wilson 95% CI lower bound 91.2%, non-overlapping with the baseline interval [14.2%, 40.2%]), while a scrambled-pairing placebo fell to 5%. The same recipe's automatic false refusal on 281 well-formed claims was 1.1% (Wilson upper bound 3.09%), so the effect is boundary-specific rather than blanket refusal; SFT saturates the face, leaving the GRPO increment not separately identifiable, and ratings come from model sessions, not human experts.

medRxiv

Telling Parkinson's from Essential Tremor Without Symptoms Alone: Diffusion Similarity Networks Plus a Graph Network Reach 87.5% Balanced Accuracy on a Hold-Out Set

Parkinson's disease and essential tremor look alike early, with misdiagnosis rates of 20% to 30% even at specialized clinics, and the white-matter tracts mapped by conventional diffusion tensor imaging do not capture microstructural change inside gray matter. The study instead builds diffusion similarity networks, linking brain regions by the statistical similarity of their diffusion profiles, then filters connections with iterative permutation sampling recursive feature elimination and classifies with a graph neural network. In five-fold cross-validation on a local cohort of 100 people, the pipeline separated Parkinson's disease from essential tremor with an AUC of 0.94, and on a separate 40-person hold-out set it reached 87.5% balanced accuracy.

Before the needles turn: a multi-scale vision transformer reads drone hyperspectral imagery to flag pine wilt at the green attack stage

Pine wilt disease is hardest to catch before needles visibly discolour, and RGB drone imagery lacks the cues. A multi-scale vision transformer, LMS-ViT, was built for drone hyperspectral data, combining a spectral-spatial fusion module, a Gaussian self-attention mechanism and a multi-scale feature pyramid to model spectral differences between central pixels and neighbours. In a Japanese black pine stand in Shandong, it identified green attack and early stage trees at 87.40% and 88.21% accuracy, with 87.90% overall accuracy, a Kappa of 83.25% and 2.45 M parameters.

Swapping hill-climbing for tabu search in Bayesian network learning: PCTABU wins on sparse networks and ties on dense ones

Hybrid Bayesian network learning separates skeleton construction from score-based search, and both the search strategy (hill-climbing or tabu) and the scoring function (BDe, LL or BIC) change the learned structure. PCTABU pairs the PC skeleton with tabu search; against PCHC on eight real benchmark networks it did better on the sparser Alarm, Child and Hailfinder, tied on the other five, and LL scored worst for both algorithms while BDe and BIC performed similarly.

Clinical history-taking stops following a fixed questionnaire: an explicit state picks each question, lifting BERTScore F1 from 0.68 to 0.84

Automated history-taking in telemedicine must collect a structured record over many turns while adapting to what the patient answers. MedAgent-RAG keeps an explicit clinical state of filled slots, a ranked differential diagnosis, questions already asked and red flags detected, selects every question from that state, and grounds its final assessment in clinical guidelines retrieved by a parent–child retrieval-augmented pipeline. Evaluated on the MediTOD corpus with a language-model patient simulator, it raises BERTScore F1 from 0.68 for a single-shot baseline built on the same language model to 0.84, at a cost of 15.8 turns on average.

arXiv

Exploration in physical control stops looking one step ahead: HTC2 scores multi-step futures and tops mean return in eleven of twelve settings

Exploration in physical control often relies on immediate prediction error or single-step physical change, which can miss information that only emerges over extended interaction. HTC2 trains a horizon-conditioned contrastive critic in a learned Hamiltonian phase space, uses the representation distance between a state-action and its same-episode multi-step futures as the primary curiosity signal, and modulates it with bounded multi-step Hamiltonian variation. Combined with SAC and PPO on six DeepMind Control Suite tasks, HTC2 achieves the highest mean final return in eleven of twelve settings.

arXiv

Multiple objectives stop being extra baggage: each agent learns its own preference, and the dynamic variant tops the Pareto front on four cooperative tasks

Multi-objective multi-agent reinforcement learning has treated multiple objectives as an extra optimisation dimension stacked on the multi-agent problem. MIRL instead uses that objective structure to guide cooperation: a team preference fixes the system-level trade-off while each agent carries a learnable individual preference, adjusted by meta-gradient according to subsequent team performance. On four multi-objective particle-environment tasks, MIRL-S and MIRL-D improve Pareto-front quality over five baselines, with the dynamic variant MIRL-D strongest overall.

arXiv

Straighter video representations are not always better: adversarial training straightens CNNs and transformers, but segmentation and frame prediction do not want it

Human vision is thought to use a straightened encoding of the natural visual world as it evolves in time, meaning frame-to-frame changes follow a more linear path in representation space. A study compared network architecture, different types of robustness, biologically inspired filtering and representational straightness, finding that adversarial training yields straighter representations in both CNNs and transformer-based architectures, but the effect is task-dependent and does not extend to segmentation or frame prediction, nor to other kinds of robustness. Straighter representations also give class predictions temporal stability, including on out-of-distribution data.

Flood alerts gain a 90% band: quantile LSTM ensemble flags risk across Australian catchments

Flood warning for Australian catchments now comes as a 90% prediction band rather than a single flow curve: three independently trained LSTMs give the mean flow and the 5th and 95th percentiles, and the band's position against a 15% annual exceedance threshold becomes a high, moderate or low risk label. On CAMELS-AUS, the q=0.05 Quantile-LSTM reached the lowest RMSE of 0.0801 in South Australia against 0.0963 for a conventional LSTM, while peak timing error across states ran about 1.94 to 3.12 days with peaks underestimated by roughly 30%.

arXiv

Medical image pretraining stops reading only reports: DICOM acquisition fields enter contrastive learning, lifting zero-shot CT macro-AUROC by 1.41 points

Medical vision-language pretraining learns from paired images and radiology reports, but scanner and acquisition-protocol differences can impair transfer. Meta-CLIP uses structured acquisition information in DICOM headers as a training-time prior: a kernel over numerical and categorical fields defines a bounded pairwise margin that reweights cross-modal negatives during pretraining, while inference keeps the standard dual-encoder architecture and needs no metadata. On CT-RATE it improves macro-AUROC over CT-CLIP by 1.41 points, with a 95% paired bootstrap interval of 0.96 to 1.85 points, and reaches the highest macro-AUROC on four of five chest radiography benchmarks.

NVIDIA Puts Its Self-Healing Recovery Engine on Kubernetes: Faulty Nodes Get Isolated While Training Jobs Restart Without Waiting for Root Cause

NVIDIA Mission Control 2.5 extends an autonomous recovery engine that previously served only Slurm high-performance computing workloads to Kubernetes workloads managed by NVIDIA Run:ai. Such AI factories had relied on manual intervention, static checkpointing and reactive monitoring, which does not scale to dozens of concurrent multi-node training jobs. The release splits recovery into three coordinated layers: workload placement, job recovery that uses failure history and job topology to choose restart, retry or requeue, and hardware recovery that isolates suspect nodes and runs diagnostics, so recovery need not wait for root-cause analysis.

NVIDIA Wires AI-Factory Telemetry Into One Causal Graph: 81 Alerts Become One Incident, Saving About 54 Cluster Hours

NVIDIA has introduced Minerva, an AIOps platform for AI factories that feeds telemetry from GPUs, switches, storage and training jobs into a knowledge graph updated as jobs move, then applies supervised and unsupervised models to catch the gray failures static thresholds miss. In one NVIDIA case, 81 separate events triggered by a switch restart were merged into a single incident, saving about 54 hours of cluster uptime; in another, the platform found one quietly degrading NVLink connection among roughly 400,000 interfaces. These figures come from NVIDIA's internal testing and case descriptions, within its supported scenarios.

arXiv

A verifiable proving ground for egocentric AI assistants: humans act on instructions, and the best model tops out at 20% on long-horizon guidance

Testing egocentric AI assistants has usually required real people, and the expensive, scarce interaction data left open whether today's multimodal models can actually help someone in the physical world. InteractiveWorld moves that loop into a verifiable environment: the assistant issues instructions, a human agent observes the scene, understands the instruction and acts independently, and the environment executes the action and updates what both see. InteractiveBench built on it holds 120 multi-turn tasks across six categories, each instruction shaping the outcome and scored by verifiable state-based rewards; across 12 frontier multimodal models, Claude Fable 5.1 reaches at most 20% and 25% on long-horizon Guidance and Planning tasks, respectively.

When rain and blur degrade the camera, the fusion layer learns to trust it less: 1.41 mAP gain on nuScenes rain

Camera–LiDAR bird's-eye-view fusion can mistake corrupted visual texture for useful evidence when the camera stream degrades. DARFusion recasts fusion as modality trust estimation: learned reliability cues calibrate both feature streams, and calibrated features, task-driven contexts and a compact degradation descriptor derived from camera BEV features decide how much camera evidence to use. It holds 68.4 mAP and 71.5 NDS on the clean nuScenes validation set and beats the reproduced BEVFusion baseline by 1.41 and 1.31 mAP on real rain and night subsets.

arXiv

No old samples, one autoencoder per class: TRACE cuts retained memory about 98% below TS-ACL

For behavioral classes that arrive over time, TRACE stores no historical samples and never expands a shared classifier; it feeds a frozen temporal-spectral representation to a small autoencoder per class and labels by reconstruction error. Across five multivariate time-series class-incremental benchmarks it reaches 88.85% five-dataset average final accuracy with 9.17 MiB of retained memory, about 98.26% less memory than TS-ACL, the strongest analytical baseline by average accuracy, and an approximately 33.43% relative accuracy gain on GrabMyo.

CLI agents can't reach login walls or video content: Agent Reach preinstalls the channels so one command reads them

Command-line AI agents such as Claude Code and Codex ship with search and web reading, yet they largely cannot reach platforms that require login, video subtitles and speech transcripts, Chinese platforms, or clean structured data. Agent Reach preinstalls and tests the upstream tools behind those platforms, so an agent calls them with one command in the form channel, action, arguments, and falls back to the next tool in an ordered list when the first fails. It only searches and reads, never logs in for you, and never asks for your password.

Retrieval for forecasting stops matching raw numbers: filtered trend charts cut long-horizon error

VRATF moves the comparison in retrieval-augmented forecasting from raw time series to denoised trend line charts: FFT low-pass filtering extracts the low-frequency trend, which is rendered as a 224×224 image and encoded by a frozen CLIP ViT-B/32 to build the retrieval database, with top-K neighbors selected by cosine similarity and aggregated by Gaussian-kernel weights. The retrieval forecast is fused at the prediction level with a DLinear base forecast through one learnable scalar. Across six multivariate benchmarks, VRATF reaches the lowest average MSE on four, with 0.340 on ETTh2 against 0.358 for the next-best RAFT, a 5.0% improvement.

A hearing-aid chip folds filtering and recognition into one ASIC: 160,000 square micrometres and 1.4 milliwatts after synthesis

Hearing aids must denoise and recognize speech within tight space and battery limits, and high-order finite impulse response filters cost area and power through many multiply-accumulate operations. This architecture places a memory-less, multiplier-less distributed-arithmetic FIR filter and a deep spectro neural network in one application-specific integrated circuit design, with inference using an approximate Wallace tree multiplier. Post-synthesis analysis reports 160,000 square micrometres, 1.4 milliwatts and about 2.1 milliseconds of hardware processing latency, while functional validation stays in MATLAB and prototype fabrication and real-time hardware validation remain future work.

Three agents argue a Supreme Court case: precedent retrieval lifts criminal petitioner Legal-sim to 0.8921

Judgment prediction has mostly reasoned over case facts, yet real proceedings are shaped by exchanges among judge, petitioner and respondent. ArguGenCourt assigns three independent GPT-4o agents these roles and lets them converse in rounds, seeding prompts with courtroom utterances retrieved from the factually closest precedent document. On criminal petitioner arguments, local precedent retrieval in the multi-agent setting reaches a Legal-sim of 0.8921 against 0.8288 for fact-based conversation under the same retrieval; feeding the generated arguments into judgment prediction gives 0.55 accuracy versus 0.48 for zero-shot.

arXiv

A 200,000-page Punjab assembly archive stops stalling on OCR noise: an agentic retrieval loop lifts answer F1 from about 0.18 to about 0.35

India's Punjab Vidhan Sabha records from 1950 to 2024 survive as roughly 200,000 scanned pages mixing Hindi, Punjabi and English, where broken layouts and OCR errors propagate into retrieval and question answering. The system couples layout segmentation and multi-script OCR with an agentic retrieval-augmented generation pipeline, in which an evaluator model judges whether retrieved evidence suffices and rewrites the query when it does not. On a stratified benchmark of 1,000 pages and 200 gold-annotated question-answer pairs, the optimized pipeline reaches MRR@1 of 0.810 and Hit@3 of 0.925; raising the retrieval-rewrite iteration cap from 1 to 3 lifts answer F1 from about 0.18 to about 0.35.

A paraphrase shouldn't flip a refusal: attribution consistency cuts a small tool agent's flip rate from 11.3% to 9.3%

Tool-using language model agents can refuse one phrasing of a harmful request and comply with another, and a missed refusal becomes an action. Llama-3.2-1B-Instruct was fine-tuned with LoRA on data not drawn from AgentHarm, comparing latent attribution regularization (LAR) against an augmentation-only control over three seeds. At 10% over-refusal on harmless tool tasks, LAR lowered the share of tasks with mixed refusal decisions from 25% to 19% and paraphrase-induced flips from 11.3% to 9.3%, while harmful-versus-harmless detection did not change significantly.

Coding agents move into one desktop: each gets its own workspace and session, and they can message each other

OpenBot places coding agents such as Codex, Claude Code, Grok CLI, OpenCode, Gemini, Cursor CLI and Cline CLI in one local-first desktop workspace, where each agent keeps its own workspace and conversation while sharing local queues, file transfers, an embedded browser and agent-to-agent messaging. It also offers shared desktop channel chats with one task owner, explicit delegation, and Stop, Resume, Reassign, Archive and Restore controls. The release is a development preview: after first-launch consent, agents run with danger-full-access and approvalPolicy: never, so they can read and modify files, run commands, use the network and control the browser without per-action confirmations.

JetBrains ships ThinkRail, an agentic IDE that gives each coding agent its own git worktree and branch

JetBrains has released ThinkRail, an agentic IDE that places coding agents in separate workspaces cut from a git repository, each with its own branch and working directory, so agents can work in parallel without touching the developer's checkout. It wraps the pi coding agent in an editor, terminals and review surface, and lets the agent keep project intent through a graph of SPEC.md files beside the code. Merging the good branch and deleting the rest closes the loop.

AIPOCH

A research workbench wires seven scientific databases into one permission panel, off by default and chosen by the researcher

AIPOCH Open-Science v1.0.3 connects seven scientific sources, spanning cancer imaging, pathways, lipids, structures, molecular regulation and cancer cell-line dependencies, into one local-first research workbench, and folds literature discovery, attachments and screening export into a single inbox. These sources previously differed in identifiers, query conventions and access controls, and connection was an assumed link; the release keeps discovery default-off and persists each source choice, making availability an explicit configuration. The exported screening CSV carries final verdicts, manual decisions, reasons and model probabilities, but those fields support spreadsheet review and do not establish study quality or scientific truth.