Heinrich Heine University Düsseldorf

Ewing sarcoma is genomically near-uniform yet patients fare very differently. Single-cell and spatial transcriptomics of tumors and their microenvironment in 135 patients identified five tumor-cell transcriptional states and eight niches defined by neighboring cell configurations, and niche composition sorted patients into Fusion Active, Proliferative, Immune Reactive and TME-enriched types. The Immune Reactive type, marked by interferon-activated tumor cells, had favorable survival, and the survival differences reproduced in two independent bulk transcriptomic cohorts.

Ewing sarcoma is genomically near-uniform yet patients fare very differently. Single-cell and spatial transcriptomics of tumors and their microenvironment in 135 patients identified five tumor-cell transcriptional states and eight niches defined by neighboring cell configurations, and niche composition sorted patients into Fusion Active, Proliferative, Immune Reactive and TME-enriched types. The Immune Reactive type, marked by interferon-activated tumor cells, had favorable survival, and the survival differences reproduced in two independent bulk transcriptomic cohorts.

A multi-bit LLM watermark's account identifier can be displaced without the secret key: an attacker with a few accounts of its own can make the decoder read a text as belonging to a different account.

A multi-bit LLM watermark's account identifier can be displaced without the secret key: an attacker with a few accounts of its own can make the decoder read a text as belonging to a different account.