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  1. DeepDelivery mines the human proteome for mRNA delivery scaffolds: 512 candidates, and 12 of 15 tested form particles that deliver

    DeepDelivery treats the human proteome as a candidate pool for mRNA delivery scaffolds: deep learning models trained on viral capsid proteins, filtered by a dual-model screen, nominated 512 candidates from 109,375 human sequences. Of 15 candidates tested experimentally, 12 formed mRNA-encapsulating particles and mediated functional delivery; RTL8B reached 73.2% transduction in HEK293T reporter cells, above the reference proteins Arc (56.5%), PEG10 (53.1%) and PNMA2 (67.4%). The results support human proteins as a source of modularly engineerable delivery scaffolds, while immunogenicity and in vivo behavior remain untested.

  2. arXiv

    Chiplet design space stops being a black box: LLM sets direction, Bayesian optimization does the numbers

    Feeding an LLM's parameter-adjustment directions to Bayesian optimization as a soft prior raises hypervolume on a 3D CPU-GPU chiplet design space from 0.8210 to 0.8356, and to 0.8051 on a 2.5D space without retraining.

  3. arXiv

    Distilling a single-agent carrying policy into a reusable low-level skill lets a high-level policy coordinate humanoids for sofa carrying, sofa pushing, and four-agent transport

    The work proposes a hierarchical framework that relabels successful rollouts of a single-agent physics-based human-object interaction teacher as short-horizon object-proxy displacement supervision, distilling a frozen reusable Object-oriented Motion Skill, while downstream training only learns a high-level policy that emits region-wise proxy-motion commands; in Isaac Gym with 4096 parallel environments the skill achieves better tracking than InterPhys and SkillMimic on both teacher-rollout and random proxy-motion targets, and supports two-human sofa carrying, four-human H-box and cross-box carrying, and two- and four-human sofa pushing.

  4. arXiv

    Peking University-led team distills coding ability from one-word answers: a Qwen2.5-1.5B student beats an exact nuisance-matched control by 5.34 points on HumanEval+

    The work introduces Active Taskless Distillation (ATD), which uses a public ancestor model to select unrelated prompts on which it is nearly indifferent between two ordinary words, has a privately post-trained teacher return a single word per prompt, and trains a same-ancestor student only on those prompt-word pairs; in the primary Qwen2.5-1.5B coding experiment, 5,664 single-word responses yield a 5.34 percentage-point gain on HumanEval+ over an exact nuisance-matched control, with positive mean gains also observed in scientific knowledge, commonsense reasoning, and reading comprehension across additional model generations, sizes, and families.

  5. arXiv

    Post-training capabilities leak through unrelated text: one teacher word per prompt yields a 5.34 pp gain on HumanEval+

    The authors introduce Active Taskless Distillation (ATD), which selects prompts where the teacher and student's shared public ancestor is nearly indifferent between two ordinary words, and lets a student initialized from that ancestor learn solely from the resulting prompt-word pairs, without target-task examples, teacher logits, or teacher parameters; in the primary coding experiment with Qwen2.5-1.5B, 5,664 samples yield a 5.34 pp gain on HumanEval+ over an exact nuisance-matched control, with transfer also shown in scientific knowledge, commonsense reasoning, and reading comprehension across additional model generations, sizes, and families, and functional analyses indicating the learned signal is composable and tracks the teacher's update strength.

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