Ovarian mass triage without a fixed biomarker panel: adaptive plasma proteomics reaches a summary AUC of 0.835 across five validation cohorts
Pre-operative triage of adnexal masses has relied on CA-125, HE4 and ultrasound O-RADS, all with limited sensitivity and specificity. ADAPT-MS instead retrains a classifier for each sample on the proteins actually measured, reading discovery-mode plasma mass spectrometry data directly. Across 623 samples in five independent validation cohorts the classifier reached a summary AUC of 0.835, comparable to O-RADS alone, and rose to 0.922 when combined with O-RADS.