# microbiome

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medRxiv Oct 5, 2026
Colorectal cancer recurrence after surgery gets a spatial host-microbiome readout: AUC 0.81 versus 0.45 for standard pathology
Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.
Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.
Sixth Affiliated Hospital of Sun Yat-sen University Sun Yat-sen University City Of Hope National Medical Center University of Hong Kong Tsinghua University City University of Hong Kong
Chenxi Hu（First author）Hailiang Sun（First author）Feng Guo（First author）Jianzhu Ma（Corresponding author）Peng Shi（Corresponding author）
AlphaFISH Spatial transcriptomics Transformer microbiome colorectal cancer
Biologia Futura Sep 16, 2026
Microbial diversity: the essential foundation for life on our planet
This review states that microbial diversity underpins human health, agricultural productivity, ecological balance, and ecosystem functioning, and it surveys the role of the gut microbial community in immune regulation, metabolism, and disease prevention, the contributions of interactions among plants, fungi, bacteria, and other soil microorganisms to carbon sequestration, nutrient cycling, stress resilience, and sustainable agricultural productivity in terrestrial ecosystems, and emerging microbiome-based therapies such as precision probiotics, postbiotics, faecal microbiota transplantation, and personalized microbiome medicine, while noting that multi-omic techniques, synthetic microbial genomes, microbiome engineering, and artificial intelligence enable emerging uses in agriculture, envi
This review states that microbial diversity underpins human health, agricultural productivity, ecological balance, and ecosystem functioning, and it surveys the role of the gut microbial community in immune regulation, metabolism, and disease prevention, the contributions of interactions among plants, fungi, bacteria, and other soil microorganisms to carbon sequestration, nutrient cycling, stress resilience, and sustainable agricultural productivity in terrestrial ecosystems, and emerging microbiome-based therapies such as precision probiotics, postbiotics, faecal microbiota transplantation, and personalized microbiome medicine, while noting that multi-omic techniques, synthetic microbial genomes, microbiome engineering, and artificial intelligence enable emerging uses in agriculture, envi
Shoolini University
Kriti Singh（First author, Corresponding author）
microbiome microbial diversity planetary sustainability

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Colorectal cancer recurrence after surgery gets a spatial host-microbiome readout: AUC 0.81 versus 0.45 for standard pathology

Microbial diversity: the essential foundation for life on our planet