Peng Shi

Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.

Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.