Sixth Affiliated Hospital of Sun Yat-sen University

Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.

Whether colorectal cancer recurs after resection has been judged mainly from routine pathology such as lymphovascular invasion, perineural invasion, tumor budding and Ki-67. AlphaFISH pairs a sequencing-free nanoprobe biochip with a transformer model to read 41 host transcripts and 51 bacterial genera across 149 colorectal biopsies, and in 28 patients followed for one year after surgery it predicted recurrence or metastasis with an AUC of 0.81, against 0.45 for the combined routine clinical markers. The result comes from a preprint that has not been peer reviewed, on a limited sample.

Automated angle-of-progression (AoP) measurement from intrapartum ultrasound is accurate to a few degrees on average, yet a small fraction of frames fails silently by tens of degrees. On the 501 test files of the public IUGC2025 benchmark, an ensemble of six landmark detectors ranked frames by disagreement between detectors; referring the most suspicious 5% for manual review lowered the share of errors above 20 degrees among retained frames from 1.2% to 0.2%, catching five of six. The missed case was one all six detectors underestimated with little spread between them; no difference was detected between angle-space and coordinate-space disagreement at the primary endpoint, and thresholds set on validation frames did not hold their intended referral rate on test frames.

Automated angle-of-progression (AoP) measurement from intrapartum ultrasound is accurate to a few degrees on average, yet a small fraction of frames fails silently by tens of degrees. On the 501 test files of the public IUGC2025 benchmark, an ensemble of six landmark detectors ranked frames by disagreement between detectors; referring the most suspicious 5% for manual review lowered the share of errors above 20 degrees among retained frames from 1.2% to 0.2%, catching five of six. The missed case was one all six detectors underestimated with little spread between them; no difference was detected between angle-space and coordinate-space disagreement at the primary endpoint, and thresholds set on validation frames did not hold their intended referral rate on test frames.