# CAISL

Molecular data in lung adenocarcinoma are high-dimensional relative to the number of observed events, so concatenating them into a survival model invites overfitting and unstable feature selection. CAISL writes predicted risk as a clinical Cox risk plus a sparse molecular correction, and penalizes how much that correction varies across resampled training cohorts. On 470 TCGA-LUAD patients with 119 observed deaths, mean C-index across five independent cross-validation runs was 0.7246 versus 0.6970 for clinical Cox, a paired gain of 0.0276 (95% CI 0.005–0.050); this is internal validation and still needs an independent cohort.

Molecular data in lung adenocarcinoma are high-dimensional relative to the number of observed events, so concatenating them into a survival model invites overfitting and unstable feature selection. CAISL writes predicted risk as a clinical Cox risk plus a sparse molecular correction, and penalizes how much that correction varies across resampled training cohorts. On 470 TCGA-LUAD patients with 119 observed deaths, mean C-index across five independent cross-validation runs was 0.7246 versus 0.6970 for clinical Cox, a paired gain of 0.0276 (95% CI 0.005–0.050); this is internal validation and still needs an independent cohort.