Frontier models already design high-risk mutations: 21.4% land in the top risk decile without tools, 23.5% with biological design tools
DRYLAB-Bench puts 15 frontier models through 30 hazardous mutation-design scenarios and scores submitted amino-acid substitutions against published wet-lab measurements: 21.4% land in each assay's highest-risk decile without tools, rising to 23.5% with biological design tools and multi-round iteration.