DRYLAB-Bench puts 15 frontier models through 30 hazardous mutation-design scenarios and scores submitted amino-acid substitutions against published wet-lab measurements: 21.4% land in each assay's highest-risk decile without tools, rising to 23.5% with biological design tools and multi-round iteration.
This MIT Technology Review article surveys concerns voiced by AI company leaders and researchers that AI could aid the design, creation, and release of bioweapons, citing the 2022 case in which Collaborations Pharmaceuticals' AI "molecule generator" produced 40,000 molecules with potential as chemical warfare agents in under six hours and Anthropic's report acknowledging attempts to use its models to explore making chikungunya virus more transmissible and creating a more dangerous bird flu, while also presenting dissenting views from some Imperial College London biologists that AI tools are not yet good enough to fully develop bioweapons and that the greatest pandemic risk comes from already-circulating pathogens such as H5N1, and summarizing existing safeguards—DNA order screening, red-te
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