CADS scores an LLM proposer against the same screen with the LLM removed, and raw hit counts overstate its gain
In sequential biological screens, LLM-proposed candidates are usually credited by hit counts, but the re-selection policy and random fallback also produce hits on their own. CADS runs the full loop beside an otherwise identical proposer-removed loop, certifies each discovery set separately, and reports the paired difference; in DepMap-backed simulations the no-LLM loop alone cleared the standard feedback gate, and origin counts inflated Qwen2.5-7B's net contribution from near zero to apparently positive.