Haribalan Perumalsamy

Nanoparticle neurological safety is hard to predict from material properties alone, because exposure conditions, disease context and host responses reshape outcomes. Across 893 experimental contexts from 599 neurological studies, pro-inflammatory, anti-inflammatory/resolution and apoptosis-associated responses were harmonized into a Conserved Response Axis and added layer by layer to material descriptors. With a Random Forest model, biosafety ROC-AUC rose from 0.66 with material properties alone to 0.88 with exposure and biological context and 0.90 with cellular responses; recovery rose from 0.64 to 0.77 and 0.78.

Nanoparticle neurological safety is hard to predict from material properties alone, because exposure conditions, disease context and host responses reshape outcomes. Across 893 experimental contexts from 599 neurological studies, pro-inflammatory, anti-inflammatory/resolution and apoptosis-associated responses were harmonized into a Conserved Response Axis and added layer by layer to material descriptors. With a Random Forest model, biosafety ROC-AUC rose from 0.66 with material properties alone to 0.88 with exposure and biological context and 0.90 with cellular responses; recovery rose from 0.64 to 0.77 and 0.78.