Bjørn P. Y. Kwee

This work presents AlphaBridge, a reproducible, objective, and automated toolkit, also available as a web server, that combines AlphaFold3 confidence metrics to cluster sequence motifs participating in binary interactions and subsequently in 3D interfaces of complexes, visualizes interaction interfaces within confidence limits via chord diagrams, network graphs, and summary tables of predicted interfaces and intermolecular interactions linked to interactive graphics, and was validated for scoring binary and multi-component protein complexes with real-life examples discussed.

This work presents AlphaBridge, a reproducible, objective, and automated toolkit, also available as a web server, that combines AlphaFold3 confidence metrics to cluster sequence motifs participating in binary interactions and subsequently in 3D interfaces of complexes, visualizes interaction interfaces within confidence limits via chord diagrams, network graphs, and summary tables of predicted interfaces and intermolecular interactions linked to interactive graphics, and was validated for scoring binary and multi-component protein complexes with real-life examples discussed.