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University of Maryland, College Park

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  1. bioRxiv

    One 0.23M-parameter model flags five DNA base modifications without an unmodified control, including 5hmU

    RawMod, released by a University of Maryland-led team, stacks the raw nanopore signal of many reads at each site and compares it base by base with the expected signal of the reference, so a single 0.23M-parameter model can say whether a site carries a modification without naming its type. Across 15 datasets spanning 5mC, 5hmC, 4mC, 6mA and 5hmU in bacterial, phage, plant, mouse, human and synthetic DNA, it reaches a mean AUROC of 0.964, against 0.799 for the best released model, Dorado 4mC+5mC. It needs no unmodified control from the same sample, but a modification type absent from training transfers zero-shot only when another modification of the same base was seen.

  2. arXiv

    Multi-agent systems stop sharing one workflow: OOPMAS builds agents and workflows per query, reaching 89.6% on mixed tasks

    Automated design of multi-agent systems has mostly worked at the task level, optimizing one fixed workflow per benchmark and applying it to every query. OOPMAS moves design to the individual query: a frozen LLM as meta-agent first generates object-style agents with roles, tools and persistent state, then an executable main-function workflow, while a dynamic skill library accumulates structured lessons from execution feedback without gradient updates. On a benchmark mixing code, math and QA, OOPMAS reaches 89.6% overall accuracy, 18.1 percentage points above the strongest baseline, ADAS.

  3. arXiv

    Scientific agents stall on judgment: four of five frontier models pick the plan a senior researcher overruled

    A new benchmark turns senior researchers' corrections of scientific AI agents into 248 two-way judgment questions: given only the project record from before the correction, four of five frontier models more often chose the original plan that a human had overruled, topping out at 63.5% against 73.4% for fresh researchers. The cases come from 26 real projects across six fields run over roughly half a year, and each asks a model to choose between the original plan and the human-corrected alternative.

  4. arXiv

    Few-shot distillation stops feeding only facts: pairing hard samples with counterfactual contexts beats factual-only baselines in most QA settings

    Few-shot distillation performance depends heavily on which training samples are chosen, and factual samples near the teacher's decision boundary can actually degrade it. CofFeQA pairs those hard factuals with counterfactuals, minimally edited contexts that make the teacher switch to an alternative answer, adding supervision around the boundary. Across five in-domain and three out-of-domain open-book QA benchmarks with T5 and Qwen2.5, it beats factual-only distillation under the same few-shot budget in most settings, though not in every one.

  5. arXiv

    Frozen models accumulate external expertise during deployment: up to 34.2% online gain on medical tasks across six benchmarks, with zero-step transfer to other models

    The work presents a model-agnostic framework that lets frozen LLMs and VLMs keep learning during deployment through three forms of external expertise: a Skill guiding reasoning and tool use, a Knowledge Memory storing reliable facts, and a Multimodal Knowledge Base that keeps visual cases and guides the model to compare each retrieved case with the current image; an update is kept only if it helps on new cases without degrading earlier ones. Across six benchmarks and four base models, the framework improves online medical performance by up to 34.2% over the base model, generalizes to unseen cases, and transfers to other models without further optimization.

  6. arXiv

    A video-to-model framework uses U-Net and a spatio-temporal CNN to identify CBF–CLF–QP suture-thread parameters from video, reproducing thread behavior with low tracking error on unseen motions

    The work presents a video-to-model framework that first extracts an ordered suture-thread node trajectory from a monocular video using U-Net segmentation and curve tracking, then uses a spatio-temporal CNN to estimate the connectivity, stiffness, and velocity-retention parameters of a structured CBF–CLF–QP model, which simulates the thread under a user-defined needle velocity; on unseen virtual materials and a non-training flower-petal needle motion, the configured model reproduces the observed thread behavior with low tracking error and reduces manual parameter tuning.

  7. arXiv

    SWR self-supervises training environments from 500 scientific software workflows, lifting Qwen3.8-27B on Terminal-Bench 2 from 47.94% to 53.56%

    The authors introduce software-in-the-loop reconstruction (SWR), a self-supervised framework that draws reference outputs and verification targets from existing software workflows, instantiated with 500 workflows across 46 software families and six domains, where Qwen3.8-Max solves 838 tasks over three attempts and yields 1,422 verified trajectories oversampled into 3,000 reconstruction-only training examples, and supervised fine-tuning raises Qwen3.8-27B mean Terminal-Bench 2 performance from 47.94% to 53.56% while achieving the highest mean among four matched-token corpus controls on all four reported evaluations.

  8. arXiv

    After rewriting 60 ICLR submissions into 1,260 versions, AI reviewers show 'false robustness'; SciCore's dual branch lifts ICC to 0.775

    The authors formulate Rhetorical Robustness as a joint requirement (stable judgments under content-preserving rewrites plus discrimination across papers), build RobustReview from 60 anonymized ICLR 2026 submissions under 10 rhetorical conditions for 1,260 full manuscripts, and evaluate 30 reviewer configurations, finding that low rewrite sensitivity often coincides with score collapse across papers ('false robustness') and that human alignment ranks reviewers differently; they then introduce SciCore, a dual-branch reviewer that averages a full-manuscript judgment with a judgment based on an extracted structured science core, achieving a leading joint stability-discrimination profile in the primary GPT-5.5 comparison (ICC 0.775, SPR 0.652, discriminability 0.

  9. arXiv

    ATR judges dubbing lip-sync with monotonic alignment plus LLM reasoning, reaching 0.920 mean AUC across seven languages

    The work introduces Align Then Reason (ATR), in which a monotonic CTC alignment scorer between candidate-text phonetic units and frame-level lip representations supplies per-unit soft tokens and a calibrated global alignment score to an LLM reasoner that outputs a Yes/No judgment with a short explanation, raising Qwen3.5-9B mean AUC from 0.610 to 0.920 on a seven-language benchmark and improving on three unseen MuAViC languages and two real dubbing downstream tasks.

  10. arXiv

    Across 800 pretrained models, wild AI web text raises loss once data is plentiful, and a 31.1% AI share costs 1.6x the compute

    Using EditLens and Pangram to label Common Crawl web data from 2021 to 2026, the authors find that 27.5% of tokens passing FineWeb quality filtering in June 2026 are AI-generated, rising to 31.1% in August, and by pretraining 800 models from 19.9M to 973M parameters while varying the ratio of added AI to human tokens they fit a new scaling law with separate benefit and harm terms: AI tokens lower loss for data-starved models before saturating and reversing into harm, raise loss almost immediately for Chinchilla-optimal models, and the law predicts held-out sizes with lower error than eleven existing laws, implying that training at August 2026's AI share takes 1.6x the compute.