# Neural alignment of representations

Neuralign places neural recordings from different sessions and animals, with different sampled neurons, into one tensor decomposition in which each component shares a single temporal curve while trial strength and neuron weights are estimated per session, so no matched neurons or matched trials are needed. On 93 brain-wide recordings from 19 mice, an unsupervised fit yielded a single component that separated the three anterior lateral motor cortex (ALM) optogenetic inhibition conditions, with balanced accuracy of 0.647 on held-out sessions against a chance level of 1/3. That component's change showed a modest association with the drop in behavioural accuracy (ρ = 0.266 over 180 session–inhibition observations).

Neuralign places neural recordings from different sessions and animals, with different sampled neurons, into one tensor decomposition in which each component shares a single temporal curve while trial strength and neuron weights are estimated per session, so no matched neurons or matched trials are needed. On 93 brain-wide recordings from 19 mice, an unsupervised fit yielded a single component that separated the three anterior lateral motor cortex (ALM) optogenetic inhibition conditions, with balanced accuracy of 0.647 on held-out sessions against a chance level of 1/3. That component's change showed a modest association with the drop in behavioural accuracy (ρ = 0.266 over 180 session–inhibition observations).