Breast cancer age-linked genes fall from 80 to four: only IL7R, SQSTM1, EGR1 and IGF1 survive replication and receptor robustness
Age-associated gene expression signals in breast tumors narrow from 80 to four candidates, IL7R, SQSTM1, EGR1 and IGF1, after receptor and stage adjustment, cross-platform replication and estrogen-receptor stratification. The same molecular workflow is also encoded as a bounded symbolic controller that completes, blocks or fails safe against a prespecified reference policy across 760 scenarios, rather than only finishing. The output is research prioritization, not a clinical biomarker or treatment recommendation.