PRAXIS-VirtualCell proposes a modular framework that organizes biological data, models, perturbations, and validation evidence, using biological contracts and evidence-aware execution to separate supported predictions from extrapolation and abstention across E. coli, S. cerevisiae, and human K562 cells.
The work presents PRAXIS-VirtualCell, a modular framework that organizes biological data, predictive models, perturbations, adapters, execution environments, and validation evidence to enable reproducible and auditable virtual experiments; the system supports cross-species tasks spanning Escherichia coli, Saccharomyces cerevisiae, and human K562 cells, uses biological contracts and evidence-aware execution to distinguish supported predictions from extrapolation and abstention, and integrates agentic orchestration to translate natural-language questions into traceable virtual experiments.