# Cellpose-SAM

The work proposes a pre-specified retention protocol and applies it to several post-training quantization schemes for Cellpose–SAM on a stratified 176-field public panel spanning BBBC038 nuclei, BBBC039 U2OS fluorescence, and NIST iPSC images: weight-only W8A16 preserves instance F1 across all modalities, a sensitivity-guided mixed W4/W8 scheme with four INT8 exception operators reduces weight storage from 1162.07 MiB to 171.86 MiB with no observed catastrophic failures, while ternary W2A16-G64 compresses to 96.21 MiB but fails catastrophically on 169 of 176 fields, showing that compression should be judged by modality-stratified downstream retention rather than a single accuracy number.

The work proposes a pre-specified retention protocol and applies it to several post-training quantization schemes for Cellpose–SAM on a stratified 176-field public panel spanning BBBC038 nuclei, BBBC039 U2OS fluorescence, and NIST iPSC images: weight-only W8A16 preserves instance F1 across all modalities, a sensitivity-guided mixed W4/W8 scheme with four INT8 exception operators reduces weight storage from 1162.07 MiB to 171.86 MiB with no observed catastrophic failures, while ternary W2A16-G64 compresses to 96.21 MiB but fails catastrophically on 169 of 176 fields, showing that compression should be judged by modality-stratified downstream retention rather than a single accuracy number.