# Microproteins

Combining mass spectrometry, RNA sequencing and ribosomal profiling on 608 post-mortem dorsolateral prefrontal cortex samples from individuals with and without Alzheimer's disease, the study identified 4,321 microproteins (3,217 of them not previously characterized in the UniProtKB/Swiss-Prot standard human protein catalogue), applied a deep-learning model to rank the mass-spectrometry identification confidence of 3,001 of them with 1,067 rated high confidence, and found dozens of microproteins with altered expression in people with Alzheimer's disease, producing what is described as the largest atlas of microproteins in Alzheimer's disease made so far and making the dataset publicly available.

Combining mass spectrometry, RNA sequencing and ribosomal profiling on 608 post-mortem dorsolateral prefrontal cortex samples from individuals with and without Alzheimer's disease, the study identified 4,321 microproteins (3,217 of them not previously characterized in the UniProtKB/Swiss-Prot standard human protein catalogue), applied a deep-learning model to rank the mass-spectrometry identification confidence of 3,001 of them with 1,067 rated high confidence, and found dozens of microproteins with altered expression in people with Alzheimer's disease, producing what is described as the largest atlas of microproteins in Alzheimer's disease made so far and making the dataset publicly available.