# Machine Translation

Enzyme engineering has relied on directed evolution, which screens thousands of variants even though fewer than 5% of single mutations are beneficial. REXzyme recasts enzyme design as translation: an encoder reads a reaction written in SMILES and a decoder generates an amino acid sequence token by token, after training on about 21 million reaction-enzyme pairs. Steered toward the reverse reaction of formate dehydrogenase, the reduction of CO2 to formate, all 20 designs generated after family-specific fine-tuning and reinforcement-learning alignment expressed as soluble proteins and showed activity, and design C20 reached a specific activity of 80.8 mU/mg, 2.5 times that of wild-type CtFDH.

Enzyme engineering has relied on directed evolution, which screens thousands of variants even though fewer than 5% of single mutations are beneficial. REXzyme recasts enzyme design as translation: an encoder reads a reaction written in SMILES and a decoder generates an amino acid sequence token by token, after training on about 21 million reaction-enzyme pairs. Steered toward the reverse reaction of formate dehydrogenase, the reduction of CO2 to formate, all 20 designs generated after family-specific fine-tuning and reinforcement-learning alignment expressed as soluble proteins and showed activity, and design C20 reached a specific activity of 80.8 mU/mg, 2.5 times that of wild-type CtFDH.

Preferred Networks released PLaMo 3 Translate, a translation-specialized LLM suite originally built for its own PLaMo Translate service, as open weights on Hugging Face in four sizes (0.8B, 2B, 8B, 31B), runnable entirely offline on smartphones, laptops or internal corporate servers across 53 languages including English and Japanese. Under the PLaMo Community License, individuals and enterprises with annual revenue of 1 billion yen or less in their most recent fiscal year can download and use the models free for commercial and non-commercial purposes; larger organizations need a commercial license. PFN says its comparative evaluations put even the smallest 0.8B version ahead of comparable translation-specific LLMs such as Google's TranslateGemma and Tencent's Hy-MT2.

Preferred Networks released PLaMo 3 Translate, a translation-specialized LLM suite originally built for its own PLaMo Translate service, as open weights on Hugging Face in four sizes (0.8B, 2B, 8B, 31B), runnable entirely offline on smartphones, laptops or internal corporate servers across 53 languages including English and Japanese. Under the PLaMo Community License, individuals and enterprises with annual revenue of 1 billion yen or less in their most recent fiscal year can download and use the models free for commercial and non-commercial purposes; larger organizations need a commercial license. PFN says its comparative evaluations put even the smallest 0.8B version ahead of comparable translation-specific LLMs such as Google's TranslateGemma and Tencent's Hy-MT2.

PFN released PLaMo 3 Translate, the translation-focused large language model behind its PLaMo translation service, as open-weight models in four sizes, 0.8B, 2B, 8B and 31B, which can be embedded in phones, laptops or in-house servers to translate among 53 languages including Japanese and English without a network connection. By PFN's own evaluation, the smallest model scores above Google's TranslateGemma and Tencent's Hy-MT2 on translation quality, and companies and individuals with revenue or sales of 1 billion yen or less in the latest fiscal year may use it commercially for free under the PLaMo Community License.

PFN released PLaMo 3 Translate, the translation-focused large language model behind its PLaMo translation service, as open-weight models in four sizes, 0.8B, 2B, 8B and 31B, which can be embedded in phones, laptops or in-house servers to translate among 53 languages including Japanese and English without a network connection. By PFN's own evaluation, the smallest model scores above Google's TranslateGemma and Tencent's Hy-MT2 on translation quality, and companies and individuals with revenue or sales of 1 billion yen or less in the latest fiscal year may use it commercially for free under the PLaMo Community License.