# DECIPHER

The authors present DECIPHER, an end-to-end representation-learning framework for cell-type deconvolution that learns a domain-constant representation (Zc) for deconvolution and a domain-specific representation (Zs) to model domain-associated variation, estimates cell-type proportions from Zc via differentiable non-negative least-squares optimization, shows robust and competitive deconvolution performance across simulated datasets, experimentally generated bulk-cell mixtures, real-world datasets and multiple molecular modalities, and further shows that the learned Zc supports chronological age prediction across independent cohorts and prognostic stratification in lung adenocarcinoma.

The authors present DECIPHER, an end-to-end representation-learning framework for cell-type deconvolution that learns a domain-constant representation (Zc) for deconvolution and a domain-specific representation (Zs) to model domain-associated variation, estimates cell-type proportions from Zc via differentiable non-negative least-squares optimization, shows robust and competitive deconvolution performance across simulated datasets, experimentally generated bulk-cell mixtures, real-world datasets and multiple molecular modalities, and further shows that the learned Zc supports chronological age prediction across independent cohorts and prognostic stratification in lung adenocarcinoma.