# B-cell epitope prediction

B-cell epitope prediction has been constrained by scarce experimentally annotated data, and CARTnet feeds sequence, structure, physicochemical features and an optional epitope template into an attention network with contact bias. On a 61-target internal test set its no-template version reached an AUPRC of 0.243 against 0.220 for DiscoTope-3, and on a 52-target external set it reached 0.267 against 0.215 for BepiPred-3. The template-guided variant rose from 0.225 to 0.403 AUPRC on the internal set with a single template residue, though the gain saturated as more templates were supplied.

B-cell epitope prediction has been constrained by scarce experimentally annotated data, and CARTnet feeds sequence, structure, physicochemical features and an optional epitope template into an attention network with contact bias. On a 61-target internal test set its no-template version reached an AUPRC of 0.243 against 0.220 for DiscoTope-3, and on a 52-target external set it reached 0.267 against 0.215 for BepiPred-3. The template-guided variant rose from 0.225 to 0.403 AUPRC on the internal set with a single template residue, though the gain saturated as more templates were supplied.