Vaginal dysbiosis need not rely on antibiotics alone: two Lactiplantibacillus plantarum strains cut Gardnerella in mice to near-healthy levels
From 88 lactobacilli isolates from human milk, infant stool and fermented foods, two Lactiplantibacillus plantarum strains, CYLB2146 and CYLB2189, inhibited Gardnerella vaginalis, Streptococcus agalactiae, Neisseria gonorrhoeae and Candida spp. and lowered inflammatory cytokines in vaginal epithelial cells. In a murine bacterial vaginosis model, live bacteria and their cell-free supernatants reduced G. vaginalis loads from 51.2- and 41.6-fold in controls to 3.2-, 11.1-, 3.2- and 0.7-fold after 5 days, approaching healthy levels by day 10.