BrainSTR models dynamic brain networks with spatio-temporal contrastive learning, validated on ASD, BD, and MDD with critical phases and subnetworks consistent with prior neuroimaging findings
The work proposes BrainSTR, a spatio-temporal contrastive learning framework that learns state-consistent phase boundaries via a data-driven Adaptive Phase Partition module, identifies diagnostically critical phases with attention, and extracts disease-related connectivity within each phase using an Incremental Graph Structure Generator regularized by binarization, temporal smoothness, and sparsity; a spatio-temporal supervised contrastive learning approach then leverages diagnosis-relevant spatio-temporal patterns to refine the similarity metric between samples and build a well-structured semantic space. Experiments on ASD, BD, and MDD validate its effectiveness, and the discovered critical phases and subnetworks provide interpretable evidence consistent with prior neuroimaging findings.