# Glyph

Glyph decomposes clinical foundation-model embeddings into sparse, nameable concepts so that features previously entangled in high-dimensional vectors can be tested like clinical variables. Across abdominal CT, radiology reports and laboratory data from 41,628 patients, the study tested 604,185 concept–outcome pairs and retained 397 high-risk concepts with 4,463 Bonferroni-significant associations. Most associations reproduced in three held-out cohorts without recalibration, and the top ten concepts reproduced more often than markers recovered from the literature.

Glyph decomposes clinical foundation-model embeddings into sparse, nameable concepts so that features previously entangled in high-dimensional vectors can be tested like clinical variables. Across abdominal CT, radiology reports and laboratory data from 41,628 patients, the study tested 604,185 concept–outcome pairs and retained 397 high-risk concepts with 4,463 Bonferroni-significant associations. Most associations reproduced in three held-out cohorts without recalibration, and the top ten concepts reproduced more often than markers recovered from the literature.