Brain connectome alignment drops the shared-coordinate assumption: Ossa learns a rotation and a sparse node set, beating size-matched baselines on held-out ABCD alignment
Structural and functional connectivity live in different coordinate systems, and prior analyses either summarized coupling with one whole-connectome correlation or scored regions one at a time, without naming a compact set of regions that carries the functional organization. Ossa puts an orthogonal rotation of functional connectivity and a sparse node-selection vector into one objective, seeking within each functional community the structural subgraph that best matches functional geometry. In simulation under full rotation the node set reached a Jaccard of 0.861, held-out alignment on the ABCD baseline and Year-2 follow-up exceeded size-matched baselines, and the selected supports replicated across visits with a Jaccard of 0.928.