# Bloom

The Allen Institute for Brain Science and AWS have released Bloom, a single-cell multimodal model that encodes gene expression and chromatin accessibility into one shared cell representation while training on roughly 100-fold fewer cells than comparable pretrained models. On adult mouse whole-brain data, linear classifiers on Bloom embeddings reach 91% cross-validated adjusted balanced accuracy for 315 subclasses (multiome), 94% for 310 subclasses (scRNA-seq) and 94% for 297 subclasses (snRNA-seq), although the model saw only mouse multiome data.

The Allen Institute for Brain Science and AWS have released Bloom, a single-cell multimodal model that encodes gene expression and chromatin accessibility into one shared cell representation while training on roughly 100-fold fewer cells than comparable pretrained models. On adult mouse whole-brain data, linear classifiers on Bloom embeddings reach 91% cross-validated adjusted balanced accuracy for 315 subclasses (multiome), 94% for 310 subclasses (scRNA-seq) and 94% for 297 subclasses (snRNA-seq), although the model saw only mouse multiome data.