vLLM runs Mistral Large 4 on day one: NVFP4 decodes 1.08–1.19x faster than FP8 with about 1.5x the KV cache
vLLM added same-day inference support for Mistral Large 4, a 1-trillion-parameter sparse mixture-of-experts multimodal model with 49 billion parameters active per token. The work spans breakable CUDA graphs, hand-written fusions, decode and prefill context parallelism, DSpark speculative decoding, NIXL disaggregated serving and host-memory KV offload. On TP8, NVFP4 decodes 1.08–1.19x faster per token than FP8 and holds about 1.5x the KV cache, while staying within 2.1 points of FP8 on multimodal and long-context evaluations.