Licyel Paulas-Condori

Culture conditions combine continuous doses, so testing them exhaustively is impractical, and earlier work could only rank predefined candidate designs or search a discrete catalogue. LabCompass couples a flow-matching generative model with a forward surrogate that predicts cell phenotypes, using the surrogate's gradient at inference time to steer sampling toward recipes expected to produce a target cell state. In primary human cord-blood CD34+ cells, four experimental loops produced a 78-million-cell spectral flow cytometry dataset, recovered a known megakaryocyte-inducing recipe the model had never seen, and raised erythroid progenitors to 22%, roughly 1.6-fold over the control condition.

Culture conditions combine continuous doses, so testing them exhaustively is impractical, and earlier work could only rank predefined candidate designs or search a discrete catalogue. LabCompass couples a flow-matching generative model with a forward surrogate that predicts cell phenotypes, using the surrogate's gradient at inference time to steer sampling toward recipes expected to produce a target cell state. In primary human cord-blood CD34+ cells, four experimental loops produced a 78-million-cell spectral flow cytometry dataset, recovered a known megakaryocyte-inducing recipe the model had never seen, and raised erythroid progenitors to 22%, roughly 1.6-fold over the control condition.