Kenta Nakai

Most ICU sepsis warning models answer only whether sepsis will occur, leaving clinicians unsure of the onset context and early course once an alarm sounds. SepsisFlow places hourly pre-onset risk, the patient state at onset and the 72-hour organ-support trajectory on one clock advancing hourly from ICU admission: before onset it uses only bedside-visible records without antimicrobial or culture orders, reaching a 24-hour AUROC of 0.822 on the MIMIC-IV internal test set, and its onset states form three contexts with 28-day in-hospital mortality of 17.1%, 15.1% and 2.2%.

Most ICU sepsis warning models answer only whether sepsis will occur, leaving clinicians unsure of the onset context and early course once an alarm sounds. SepsisFlow places hourly pre-onset risk, the patient state at onset and the 72-hour organ-support trajectory on one clock advancing hourly from ICU admission: before onset it uses only bedside-visible records without antimicrobial or culture orders, reaching a 24-hour AUROC of 0.822 on the MIMIC-IV internal test set, and its onset states form three contexts with 28-day in-hospital mortality of 17.1%, 15.1% and 2.2%.