Sha Sun

This work develops a continuum-based reaction-diffusion model of XIST-mediated gene silencing spread on chromosomes, finding that XIST spread can be tuned by known negative feedback loops regulating its synthesis and degradation, while silencing spread is controlled by a wave-pinning mechanism driven by global regulation of the silencing complex together with local epigenetic regulators, and uses a 3D chromosome structure inferred from experimental data to show spatiotemporal regulation of silencing spread.

This work develops a continuum-based reaction-diffusion model of XIST-mediated gene silencing spread on chromosomes, finding that XIST spread can be tuned by known negative feedback loops regulating its synthesis and degradation, while silencing spread is controlled by a wave-pinning mechanism driven by global regulation of the silencing complex together with local epigenetic regulators, and uses a 3D chromosome structure inferred from experimental data to show spatiotemporal regulation of silencing spread.