Team builds a single-nucleus multi-omic atlas across 21 adult human tissues, profiling 459,856 transcriptomic and chromatin accessibility profiles and identifying 161,270 novel regulatory elements
The study presents a single-nucleus multi-omic atlas comprising 459,856 transcriptomic and chromatin accessibility profiles from 21 adult human tissues and four donors, including paired measurements from 160,688 nuclei, resolving nine cell lineages, 61 broad cell types and 313 subclusters, identifying 1,085,062 candidate cis-regulatory elements (including 161,270 novel elements absent from ENCODE), and using the dataset to train sequence-to-function models that predict chromatin-accessibility effects for 548,656 fine-mapped variants, identifying 18,133 high-effect variants including 1,120 broadly active variants.