Li-Fan Peng

In a retrospective cohort of 1,286 men with non-obstructive azoospermia at two reproductive medicine centers, intraoperative AI-SpermScope marking of likely spermatogenic tubules and rapid sperm confirmation raised sperm retrieval success to 68.1% versus 47.6% for conventional micro-TESE, a gap that persisted after propensity score matching. Among men with retrieved sperm, the subsequent ICSI live birth rate per transfer cycle was 38.5% in the AI group and 26.8% in the conventional group; group assignment was not randomized, so a causal effect still needs prospective randomized trials.

In a retrospective cohort of 1,286 men with non-obstructive azoospermia at two reproductive medicine centers, intraoperative AI-SpermScope marking of likely spermatogenic tubules and rapid sperm confirmation raised sperm retrieval success to 68.1% versus 47.6% for conventional micro-TESE, a gap that persisted after propensity score matching. Among men with retrieved sperm, the subsequent ICSI live birth rate per transfer cycle was 38.5% in the AI group and 26.8% in the conventional group; group assignment was not randomized, so a causal effect still needs prospective randomized trials.