BiasRecon hits top PSNR in cross-anatomy, cross-center and cross-modality MRI reconstruction with fewer than 100 tunable parameters
The work proposes BiasRecon, a bias-calibrated adaptation framework grounded in a minimal-intervention principle, which alternates frequency-guided prior calibration (learnable scalars α and β modulating low- and high-frequency components at each U-Net skip layer, adding only 2L parameters), score-based denoising, and adaptive regularization that uses Stein's Unbiased Risk Estimator (SURE) to tune the regularization parameter γ; trained on FastMRI knee (973 volumes) and evaluated without retraining on FastMRI-Brain (cross-anatomy), Stanford Knee (cross-center) and CMRxRecon (combined shift) under 8× Gaussian 1D undersampling, it improves PSNR over DDS by +1.19 dB, +2.06 dB and +1.60 dB respectively, and is best in 10 of 12 sampling/acceleration settings.