Asal Roudbari

TRACE maps longitudinal visit records to interpretable progression phenotypes and lets the number of phenotypes exceed the number of diagnostic classes. In the label-matched setting on the ADNI cohort it achieves the highest purity, NMI, ARI, silhouette index, accuracy and macro-F1 at the current, 12-month and 24-month horizons; at 24 months it exceeds the strongest baseline by 3.1 and 5.8 percentage points in purity and silhouette index. With the phenotype count freed, it splits a new phenotype out of the cognitively-normal- and MCI-dominant groups, one whose cognitive-scale trajectories sit in between while its hippocampal-volume trajectory coincides with the MCI group.

TRACE maps longitudinal visit records to interpretable progression phenotypes and lets the number of phenotypes exceed the number of diagnostic classes. In the label-matched setting on the ADNI cohort it achieves the highest purity, NMI, ARI, silhouette index, accuracy and macro-F1 at the current, 12-month and 24-month horizons; at 24 months it exceeds the strongest baseline by 3.1 and 5.8 percentage points in purity and silhouette index. With the phenotype count freed, it splits a new phenotype out of the cognitively-normal- and MCI-dominant groups, one whose cognitive-scale trajectories sit in between while its hippocampal-volume trajectory coincides with the MCI group.