A Six-Million-Cell Map of Gene Activity in the Human Prefrontal Cortex: How the PsychAD Cohort and Dreamlet Push Brain-Disease Research to Population Scale
A single-nucleus RNA-sequencing atlas of the human dorsolateral prefrontal cortex built from nearly 1,500 donors and more than 6.3 million nuclei, together with the companion statistical tool Dreamlet, characterizes cell-type-specific transcriptional changes across eight brain disorders, reports shared cross-disease signatures, cell-composition shifts along Alzheimer's disease progression, and marked up-regulation of PTPRG in microglia.