Yi Han

Sepsis-induced cardiomyopathy is heterogeneous and lacks agreed diagnostic criteria, so conventional echo measures and troponin capture only part of the dynamic change. A physiology-informed model cuts apical four-chamber loops into end-diastole-to-end-diastole cycles, derives left-ventricular area features, and fuses them with EchoJEPA visual representations and phase-aware attention before aggregating beats to a patient-level probability. In a 93-patient MIMIC-IV-ECHO external cohort it reached an AUROC of 0.929, against 0.735 for direct EchoJEPA classification, a paired difference of 0.194.

Sepsis-induced cardiomyopathy is heterogeneous and lacks agreed diagnostic criteria, so conventional echo measures and troponin capture only part of the dynamic change. A physiology-informed model cuts apical four-chamber loops into end-diastole-to-end-diastole cycles, derives left-ventricular area features, and fuses them with EchoJEPA visual representations and phase-aware attention before aggregating beats to a patient-level probability. In a 93-patient MIMIC-IV-ECHO external cohort it reached an AUROC of 0.929, against 0.735 for direct EchoJEPA classification, a paired difference of 0.194.