In simulations built on two randomized controlled trial datasets, Cox proportional hazards and random survival forest performance diverged by performance measure and proportional hazards assumption
The authors conducted a comprehensive neutral simulation comparison based on two reference datasets from randomized controlled trials, evaluating the Cox proportional hazards model and random survival forest for patient-specific survival probability prediction across multiple performance measures following TRIPOD recommendations, and found that conclusions based solely on the C index may not generalize to other aspects of predictive performance, that measures of overall performance may generally give more reasonable results, that the standard log-rank splitting rule for the random survival forest may be outperformed by alternative splitting rules particularly in nonproportional hazards settings, that the random survival forest performance suffered less in data with treatment-covariate inte