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Centre for Addiction and Mental Health

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  1. arXiv

    Site-level trade-off between stochastic and nearest rounding in low-precision transformer inference: SR in the MLP with RN at the head brings perplexity to 1.10x the full-precision reference

    The work extends the PRISM vectorized rounding library to arbitrary virtual precision via a variable-precision stochastic rounding (VPSR) algorithm and, holding the numerical format fixed while varying only the rounding rule at individual operation sites, emulates DistilGPT-2; it supports the site-level trade-off with a probabilistic forward-error bound for linear projections and a second-order decomposition of expected cross-entropy at the softmax, finding that at t=6 significand bits SR in the MLP gives 1.15x the full-precision reference perplexity versus 2.21x for RN, that the ordering reverses at the language-model head, and that a mixed-precision configuration (MLP output at t=6, SR in the MLP, RN at the head) brings perplexity within 1.10x, a 28% reduction over matched-bit RN.

  2. A 45-member modified Delphi consensus: screen for eating disorders before GLP-1 receptor agonist prescribing, and generally avoid these agents in active anorexia and bulimia nervosa

    Using a three-round modified Delphi method, a 45-member panel of clinicians and researchers in diabetes, obesity and/or eating disorders plus people with lived experience reached an average 91.7% consensus on recommendations for GLP-1 receptor agonist use in eating disorder contexts, covering pre-treatment screening, risk-stratified monitoring, standardized educational materials and concurrent evidence-based psychotherapy, stating that these agents should generally be avoided in active eating disorders, particularly anorexia nervosa, atypical anorexia nervosa and bulimia nervosa with marked dietary restraint and/or significant weight suppression, and setting out research priorities in epidemiology, regulation and binge eating disorder trials.

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