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Marche Polytechnic University

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bioRxiv Nov 4, 2026
A snapshot can rank a mouse's age: within-session ordering hits 65%, and mice that look older are frailer with 14% higher death hazard
A laboratory mouse's age can be read from an ordinary photograph, but what transfers is relative age rather than absolute age. Across 2,846 photographs of 1,292 mice from seven facilities, a frozen DINOv2 vision model with ridge regression predicted age; on unseen facilities the median absolute error was 138 days, yet within a session the older of two mice was ranked older in 65% of pairs, rising above 95% for age gaps over 500 days. Mice predicted older than their age were frailer, with each 100 days of photographic age gap linked to 0.12 SD more frailty and a 14% higher hazard of death.
A laboratory mouse's age can be read from an ordinary photograph, but what transfers is relative age rather than absolute age. Across 2,846 photographs of 1,292 mice from seven facilities, a frozen DINOv2 vision model with ridge regression predicted age; on unseen facilities the median absolute error was 138 days, yet within a session the older of two mice was ranked older in 65% of pairs, rising above 95% for age gaps over 500 days. Mice predicted older than their age were frailer, with each 100 days of photographic age gap linked to 0.12 SD more frailty and a 14% higher hazard of death.
Marche Polytechnic University University of Genoa National University of Singapore Inserm Università della Svizzera italiana
Kevin Pérez（First author, Corresponding author）
Photographic age gap DINOv2 Ridge Regression Biological Age Survival analysis
Updates in Surgery Sep 15, 2026
Artificial intelligence assessment of Parkland's grading scale in laparoscopic cholecystectomy: a step toward real-world outcome prediction
In routine use of a surgical AI platform, the study automatically assigned Parkland Grading Scale scores across 249 consecutive laparoscopic cholecystectomies, grouped them into Low (PGS 1-2, n=78) and High (PGS 3-5, n=171) severity, compared surgical outcomes, and evaluated model F1, discrimination (AUC 0.932 and 0.896) and calibration against two surgeons' independent double reviews of a 75-video sample, finding that the High group had older age, higher ASA scores, more cholecystitis and urgent surgery, longer operative duration, more intraoperative events and bailouts, longer hospital stay, and more 90-day major complications and readmissions, with operative duration and hemorrhage-related events remaining significant after case-control matching (n=84).
In routine use of a surgical AI platform, the study automatically assigned Parkland Grading Scale scores across 249 consecutive laparoscopic cholecystectomies, grouped them into Low (PGS 1-2, n=78) and High (PGS 3-5, n=171) severity, compared surgical outcomes, and evaluated model F1, discrimination (AUC 0.932 and 0.896) and calibration against two surgeons' independent double reviews of a 75-video sample, finding that the High group had older age, higher ASA scores, more cholecystitis and urgent surgery, longer operative duration, more intraoperative events and bailouts, longer hospital stay, and more 90-day major complications and readmissions, with operative duration and hemorrhage-related events remaining significant after case-control matching (n=84).
Marche Polytechnic University Tel Aviv University Tel Aviv Sourasky Medical Center
Yuval Mirkin（First author）Danit Dayan（Corresponding author）
surgical outcome prediction laparoscopic cholecystectomy

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