Assistance Publique – Hôpitaux de Paris

On severe tuberculosis CT, cavities and consolidations have soft-tissue density and are left out of lung masks by segmenters such as R231. LungMend treats mask correction as shape completion: a latent diffusion prior trained on 57 healthy lungs, conditioned on a synthetically corrupted mask and on bone anatomy that disease does not alter, with no pathological data or CT intensities. On 200 radiologist-corrected slices from 20 severe TB cases it reaches 0.986 Dice and 0.57 mm average surface distance, with cavity and consolidation recall of 0.993 and 0.981.

On severe tuberculosis CT, cavities and consolidations have soft-tissue density and are left out of lung masks by segmenters such as R231. LungMend treats mask correction as shape completion: a latent diffusion prior trained on 57 healthy lungs, conditioned on a synthetically corrupted mask and on bone anatomy that disease does not alter, with no pathological data or CT intensities. On 200 radiologist-corrected slices from 20 severe TB cases it reaches 0.986 Dice and 0.57 mm average surface distance, with cavity and consolidation recall of 0.993 and 0.981.