Xuan Wu Hospital of the Capital Medical University

Using data from the TRANQUIL multicenter randomized controlled trial, this study estimated minimal clinically important differences (MCIDs) for the modified activities of daily living (mADL) and mADL11 scales of TETRAS in essential tremor via anchor-based approaches (CGI-I and PGI-I) and ROC analyses, recommending patient-report-based MCIDs of -6.2 for mADL and -4.1 for mADL11.

Using data from the TRANQUIL multicenter randomized controlled trial, this study estimated minimal clinically important differences (MCIDs) for the modified activities of daily living (mADL) and mADL11 scales of TETRAS in essential tremor via anchor-based approaches (CGI-I and PGI-I) and ROC analyses, recommending patient-report-based MCIDs of -6.2 for mADL and -4.1 for mADL11.