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Graefe s Archive for Clinical and Experimental Ophthalmology

Fellow-eye retinal age gap and high injection burden over four years in neovascular age-related macular degeneration

This retrospective cohort study of 80 treatment-naive neovascular age-related macular degeneration patients followed for at least 4 years estimated retinal age from fellow-eye fundus photographs using the publicly available Japan Ocular Imaging Registry deep learning model and computed raw retinal age gap (retinal age minus chronological age), finding no association between raw or age-corrected retinal age gap and total injection number in the count analysis, while in an exploratory threshold-based analysis the ≥ 24-injection group had higher raw retinal age gap than the < 24-injection group (4.19 vs. 0.66 years, P = 0.039) and each 1-year increase in raw retinal age gap was associated with requiring ≥ 24 injections (OR 1.11; 95% CI, 1.01-1.22; P = 0.