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arXiv

MAP-Diff anchors diffusion reverse trajectories to clinical intermediate-dose scans, lifting whole-body low-dose PET denoising PSNR from 42.48 dB to 43.71 dB

The work proposes MAP-Diff, a multi-anchor guided diffusion framework for progressive 3D whole-body PET denoising that uses clinically observed intermediate-dose scans as trajectory anchors and enforces timestep-dependent supervision to regularize the reverse process toward dose-aligned intermediate states, with anchor timesteps calibrated by degradation matching between simulated diffusion corruption and real multi-dose PET pairs and a timestep-weighted anchor loss stabilizing stage-wise learning; at inference it requires only ultra-low-dose input while enabling progressive, dose-consistent intermediate restoration; on internal (Siemens Biograph Vision Quadra) and cross-scanner (United Imaging uEXPLORER) datasets, compared with 3D DDPM it improves internal PSNR from 42.48 dB to 43.