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Journal of imaging informatics in medicine

Longitudinal Opportunistic T12 CT-BMD Assessment from Serial Health-Checkup Chest CT in Midlife Women

In this single-center retrospective study of 1,034 women aged 45-65 undergoing health checkups, 4,185 serial noncontrast chest CT examinations were used to derive AI-quantified T11 and T12 bone mineral density and build individual longitudinal trajectories, showing that women with low baseline bone status defined as mean T11-T12 AI-derived CT-BMD <= 128 mg/cm3 had smaller absolute BMD loss (10.82 vs 12.52 mg/cm3; P = 0.022) and a less negative T12 slope (-3.08 vs -3.91 mg/cm3/year; P = 0.011), while the greater relative decline seen in unadjusted analysis was not sustained after covariate adjustment or T11-only sensitivity analysis, and adding T11 BMD to clinical variables gave no clear incremental discrimination for rapid loss (AUC 0.708 vs 0.716; P = 0.128).