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arXiv

EpiWorld grounds LLM policy agents in an epidemiological world model, cutting cumulative hospitalisation by up to 59% on retrospective COVID-19 and Influenza data

EpiWorld is a closed-loop framework that grounds an LLM policy actor in a learned action-conditioned epidemiological world model and a tiered skill library of public-health protocols, surveillance tools, and lessons accumulated through after-action analysis; the world model predicts regional epidemic evolution and enables fast counterfactual rollouts that feed policy selection and refinement, and on retrospective COVID-19 and Influenza datasets it achieves the best out-of-distribution Peak-MAE among forecasting baselines while the closed-loop framework reduces cumulative hospitalisation by up to 59% across datasets and by an average of about 16% across six LLM backbones, outperforming reinforcement-learning and optimal-control policy baselines.