Public articles linked to the same research event.
Cancer biotherapy & radiopharmaceuticals In a prospective single-center cohort of 143 patients with clinically localized prostate cancer (cT1-2N0M0) undergoing laparoscopic radical prostatectomy, the study measured preoperative serum bone metabolism indicators such as osteocalcin N-terminal mid-fragment and alkaline phosphatase, extracted biparametric MRI radiomics variables including apparent diffusion coefficient mean and K trans mean, and integrated serum and imaging biomarkers with a multivariate logistic regression model; the integrated model reached an area under the ROC curve of 0.984, significantly outperforming individual biomarkers and imaging features (all p < 0.001), showed clinical net benefit with strong calibration (Hosmer-Lemeshow test p = 0.
In a prospective single-center cohort of 143 patients with clinically localized prostate cancer (cT1-2N0M0) undergoing laparoscopic radical prostatectomy, the study measured preoperative serum bone metabolism indicators such as osteocalcin N-terminal mid-fragment and alkaline phosphatase, extracted biparametric MRI radiomics variables including apparent diffusion coefficient mean and K trans mean, and integrated serum and imaging biomarkers with a multivariate logistic regression model; the integrated model reached an area under the ROC curve of 0.984, significantly outperforming individual biomarkers and imaging features (all p < 0.001), showed clinical net benefit with strong calibration (Hosmer-Lemeshow test p = 0.
In a prospective single-center cohort of 143 patients with clinically localized prostate cancer (cT1-2N0M0) undergoing laparoscopic radical prostatectomy, the study measured preoperative serum bone metabolism indicators such as osteocalcin N-terminal mid-fragment and alkaline phosphatase, extracted biparametric MRI radiomics variables including apparent diffusion coefficient mean and K trans mean, and integrated serum and imaging biomarkers with a multivariate logistic regression model; the integrated model reached an area under the ROC curve of 0.984, significantly outperforming individual biomarkers and imaging features (all p < 0.001), showed clinical net benefit with strong calibration (Hosmer-Lemeshow test p = 0.
In a prospective single-center cohort of 143 patients with clinically localized prostate cancer (cT1-2N0M0) undergoing laparoscopic radical prostatectomy, the study measured preoperative serum bone metabolism indicators such as osteocalcin N-terminal mid-fragment and alkaline phosphatase, extracted biparametric MRI radiomics variables including apparent diffusion coefficient mean and K trans mean, and integrated serum and imaging biomarkers with a multivariate logistic regression model; the integrated model reached an area under the ROC curve of 0.984, significantly outperforming individual biomarkers and imaging features (all p < 0.001), showed clinical net benefit with strong calibration (Hosmer-Lemeshow test p = 0.