Public articles linked to the same research event.
Ocular immunology and inflammation In 49 patients with vitreoretinal lymphoma (VRL) confirmed by cytopathology, immunohistochemistry, flow cytometry, and/or MYD88 PCR, host-genome metagenomic deep sequencing (MDS) of intraocular specimens cross-referenced against the Catalogue of Somatic Mutations in Cancer identified eight gene mutations associated with chemotherapeutic resistance in six specimens from four patients, including methotrexate-resistance-associated mutations in four specimens from three patients, and in one patient serial sampling at initial vitrectomy and two subsequent recurrences revealed distinct resistance-associated mutations at each time point; that patient died despite multi-agent therapy including rituximab, consolidation regimens, and lenalidomide, whereas the other three patients remained in long-te
In 49 patients with vitreoretinal lymphoma (VRL) confirmed by cytopathology, immunohistochemistry, flow cytometry, and/or MYD88 PCR, host-genome metagenomic deep sequencing (MDS) of intraocular specimens cross-referenced against the Catalogue of Somatic Mutations in Cancer identified eight gene mutations associated with chemotherapeutic resistance in six specimens from four patients, including methotrexate-resistance-associated mutations in four specimens from three patients, and in one patient serial sampling at initial vitrectomy and two subsequent recurrences revealed distinct resistance-associated mutations at each time point; that patient died despite multi-agent therapy including rituximab, consolidation regimens, and lenalidomide, whereas the other three patients remained in long-te
In 49 patients with vitreoretinal lymphoma (VRL) confirmed by cytopathology, immunohistochemistry, flow cytometry, and/or MYD88 PCR, host-genome metagenomic deep sequencing (MDS) of intraocular specimens cross-referenced against the Catalogue of Somatic Mutations in Cancer identified eight gene mutations associated with chemotherapeutic resistance in six specimens from four patients, including methotrexate-resistance-associated mutations in four specimens from three patients, and in one patient serial sampling at initial vitrectomy and two subsequent recurrences revealed distinct resistance-associated mutations at each time point; that patient died despite multi-agent therapy including rituximab, consolidation regimens, and lenalidomide, whereas the other three patients remained in long-te
In 49 patients with vitreoretinal lymphoma (VRL) confirmed by cytopathology, immunohistochemistry, flow cytometry, and/or MYD88 PCR, host-genome metagenomic deep sequencing (MDS) of intraocular specimens cross-referenced against the Catalogue of Somatic Mutations in Cancer identified eight gene mutations associated with chemotherapeutic resistance in six specimens from four patients, including methotrexate-resistance-associated mutations in four specimens from three patients, and in one patient serial sampling at initial vitrectomy and two subsequent recurrences revealed distinct resistance-associated mutations at each time point; that patient died despite multi-agent therapy including rituximab, consolidation regimens, and lenalidomide, whereas the other three patients remained in long-te